成纤维细胞在胃食管反流病中的作用研究进展  

Advances in the role of fibroblasts in gastroesophageal reflux disease

作　　者：王玮[1] 孙永顺 WANG Wei;SUN Yongshun(Shanghai University of Chinese Medicine,Shanghai 201203;Department of Spleen and Gastroenterology,Shanghai Municipul Hospital of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学,上海201203 [2]上海市中医医院脾胃病科,上海200071

出　　处：《基础医学与临床》2024年第11期1594-1597,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(82174128,81874402);上海市中医医院未来计划项目(WLJH2021ZY-MZY032)。

摘　　要：胃食管反流病(GERD)中的食管损伤是一种慢性炎性反应,成纤维细胞作为食管基质细胞,在食管黏膜屏障和食管炎性反应中扮演者重要角色。成纤维细胞与GERD的病程进展程度密切相关,在食管受损时,分泌大量胶原蛋白促进食管黏膜屏障修复;通过旁分泌信号调节免疫平衡,除了分泌炎性产物,还能与免疫细胞发生相互作用;但不适当的成纤维细胞被激活会诱导促炎和免疫抑制特性促进疾病的存在,提示其可能在疾病的发展中发挥关键作用。Esophageal damage in gastroesophageal reflux disease(GERD)is a chronic inflammation,and fibroblasts,as esophageal stromal cells,play an important role in the oesophageal mucosal barrier and oesophageal inflammation.Fibroblasts are closely associated with the degree of disease progression in GERD,secreting large amounts of collagen to promote oesophageal mucosal barrier repair during oesophageal damage,regulating immune homeostasis through paracrine signaling,and interacting with immune cells.In addition to secreting inflammatory products,but inappropriate fibroblast activation can induce a pro-inflammatory response.Activation of fibroblasts induces pro-inflammatory and immunosuppressive properties promoting the presence of disease,suggesting that they may play a key role in disease progression.

关 键 词：胃食管反流病 成纤维细胞 食管黏膜 食管炎性反应 

分 类 号：R573[医药卫生—消化系统]