骨髓间充质干细胞治疗肝衰竭的作用机制  

Mechanism of bone marrow-derived mesenchymal stem cells in the treatment of liver failure

作　　者：齐泽强 郭庭煜 吴治念 王亚东[1] QI Zeqiang;GUO Tingyu;WU Zhinian;WANG Yadong(Department of Infectious Disease,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院感染科,河北石家庄050051

出　　处：《基础医学与临床》2024年第11期1608-1612,共5页Basic and Clinical Medicine

基　　金：河北省自然科学基金(H2023206042);河北省政府临床医学优秀人才培养计划(ZF2023082)。

摘　　要：肝衰竭是临床一类急危重症肝病。骨髓间充质干细胞(BM-MSCs)具有向肝细胞分化、促进肝细胞再生,以及抑制肝细胞凋亡、坏死和炎性反应等作用,有助于修复受损的肝组织,改善肝功能,成为当前肝衰竭细胞治疗策略中极具应用潜力的一种新选择。Liver failure is a kind of acute and severe liver disease.Bone marrow-derived mesenchymal stem cells(BM-MSCs)have the function of differentiating into hepatocytes.Promotion of the regeneration of hepatocytes regeneration,inhibition of apoptosis,necrosis and inflammation of hepatocytes,may facilitate repairing damaged liver tissue and improving liver function.BM-MSCs have become a new choice with great application potential in the treatment of liver failure.

关 键 词：肝衰竭 间充质干细胞 再生 移植 

分 类 号：R575.3[医药卫生—消化系统]