外周血环状RNA在消化道肿瘤诊断中的临床应用价值研究  

Clinical application of peripheral blood circular RNA in the diagnosis of gastrointestinal tumors

作　　者：韩卓婷 林小聪(综述) 曾涛(审校) HAN Zhuoting;LIN Xiaochong;ZENG Tao(Department of Laboratory Medicine,the Second Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong 524003,China;Institute of Biochemistry and Molecular Biology,Guangdong Medical University,Zhanjiang,Guangdong 524023,China;Laboratory Medicine Center,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong 524003,China)

机构地区：[1]广东医科大学附属第二医院检验医学科,广东湛江524003 [2]广东医科大学/广东医科大学生物化学与分子生物学研究所,广东湛江524023 [3]广东医科大学附属医院检验医学中心,广东湛江524003

出　　处：《国际检验医学杂志》2024年第21期2675-2680,共6页International Journal of Laboratory Medicine

基　　金：广东省钟南山医学基金项目(ZNSXS-20240012);湛江市科技局资金资助疾病防治类专题(2021A05102)。

摘　　要：环状RNA(circRNA)是近年新型非编码RNA分子,其结构共价闭环,circRNA参与肿瘤发展各个进程,如肿瘤血管生成、上皮-间质转化(EMT)、耐药、侵袭等。CircRNA会以外泌体、微泡等形式进入血液循环,且不易被核酸酶降解,在血液循环中能够稳定存在。消化道肿瘤发生发展的进程与外周血circRNA的表达水平密切相关,外周血circRNA可能是消化道肿瘤潜在新型的非侵入性的诊断标志物。该文就circRNA在消化道肿瘤诊断价值的研究进展作一综述,着重分析外周血circRNA在消化道肿瘤诊断中的临床应用价值。Circular RNA(circRNA)is a new type of non-coding RNA molecule with covalent closed-loop structure.CircRNA is involved in various processes of tumor development,such as tumor angiogenesis,epithelial-mesenchymal transformation(EMT),drug resistance,invasion,etc.CircRNA could enter the blood circulation in the form of exosomes and microvesicles,and is not easily degraded by nuclease,and could exist stably in the blood circulation.The progression of gastrointestinal tumors is closely related to the expression level of circRNA in peripheral blood,and peripheral blood circRNA may be a potential novel non-invasive diagnostic marker for gastrointestinal tumors.This article reviews the research progress of circRNA in the diagnosis of gastrointestinal tumors,focusing on the clinical application value of peripheral blood circRNA in the diagnosis of gastrointestinal tumors.

关 键 词：外周血 环状RNA 消化道肿瘤 诊断 应用价值 

分 类 号：R730.4[医药卫生—肿瘤]