载药角膜接触镜的研究进展  

Research Progress of Drug-eluting Contact Lenses

作　　者：李妍[1] 陶涛[1] 赵雁[1] LI Yan;TAO Tao;ZHAO Yan(National Advanced Medical Engineering Research Center,China State Institute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]中国医药工业研究总院医药先进制造国家工程研究中心,上海201203

出　　处：《中国医药工业杂志》2024年第10期1318-1328,共11页Chinese Journal of Pharmaceuticals

摘　　要：由于人眼存在各种生理和解剖屏障,导致滴眼液等传统局部眼用制剂的生物利用度不足5%。而载药角膜接触镜的生物利用度可高达50%,并具有释药和矫正视力的双重功能。文章综述了载药角膜接触镜的制备方法、灭菌及质量评价的研究进展,并重点分析了不同制备方法在角膜接触镜载药和释药等方面的优劣,阐述了载药角膜接触镜关键功能属性的评价方法,以期为推动载药角膜接触镜的临床应用提供参考。Due to various physiological and anatomical barriers in the human eye,the bioavailability of topical ophthalmic preparations,such as eye drops,is less than 5%.While the bioavailability of drug-eluting contact lenses can achieve 50%,and the products have the dual functions of drug release and visual correction.This paper reviews the research progress of preparation methods,sterilization and quality evaluation of drug-eluting contact lenses.The advantages and disadvantages of different preparation methods in drug loading and release,as well as the critical functional attributes of drug-eluting contact lenses are emphasized,hoping to provide some references for promoting the clinical application of medicated contact lenses.

关 键 词：载药角膜接触镜 载药方法 质量评价 药物释放 功能属性 灭菌 研究进展 

分 类 号：R778[医药卫生—眼科] TH786[医药卫生—临床医学]