吲哚菁绿、蓝染料及双示踪法在荧光腔镜下乳腺癌前哨淋巴结活检中的临床应用效果评价  

Evaluation on the clinical application effect of indocyanine green,blue dye and dual-tracer method in sentinel lymph node biopsy under fluorescence endoscope for breast cancer

作　　者：朱迪 许希锐 罗云峰[1] 何琳赟 朱燕雯 廖玥 张普生[1] ZHU Di;XU Xirui;LUO Yunfeng;HE Linyun;ZHU Yanwen;LIAO Yue;ZHANG Pusheng(Department of Breast Surgery,General Surgery Center,Zhujiang Hospital of Southern Medical University,Guangzhou 510282,China;Department of Gastrointestinal Surgery,Huizhou First Hospital,Guangdong 516000,China)

机构地区：[1]南方医科大学珠江医院普通外科中心乳腺外科,广州510282 [2]惠州市第一人民医院胃肠外科,广东516000

出　　处：《中国临床新医学》2024年第10期1092-1097,共6页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广州市临床特色技术项目(编号:2023P-TS23);南方医科大学珠江医院医疗新技术项目(编号:202101001,XJS202301001);北京“新锐肿瘤支持治疗课题研究”项目(编号:cphcf-2022-076)。

摘　　要：目的评价吲哚菁绿(ICG)、蓝染料及双示踪法在荧光腔镜下乳腺癌前哨淋巴结活检(SLNB)中的临床应用效果。方法回顾性分析2021年4月至2022年8月南方医科大学珠江医院普通外科中心乳腺外科以ICG联合蓝染料双示踪法在荧光腔镜下行SLNB的166例乳腺癌患者的临床资料。比较SLN及转移性SLN在腔镜荧光模式、高清白光模式及荧光+白光双示踪模式下的显影情况,比较三种模式下SLN及转移性SLN的检出率、检出数,分析三种方法在腔镜下的示踪性能。结果166例患者共检出610枚SLN。其中48例患者检出SLN转移,并行腔镜腋窝淋巴结清扫术,检出转移性SLN 95枚。双示踪组SLN检出率(98.19%)显著高于蓝染料组(82.53%)(P<0.05),但与ICG组SLN检出率(94.58%)比较差异无统计学意义(P>0.05)。双示踪组检出SLN数[(3.52±1.72)枚]显著高于蓝染料组[(1.95±1.68)枚](P<0.05),但与ICG组检出SLN数[(3.36±1.82)枚]比较差异无统计学意义(P>0.05)。结论ICG联合蓝染料双示踪法荧光腔镜SLNB具有较高的SLN检出率,检出SLN数更多。Objective To evaluate the clinical application effect of indocyanine green(ICG),blue dye and dual-tracer method in sentinel lymph node biopsy(SLNB)under fluorescence endoscope for breast cancer.Methods The clinical data of 166 patients with breast cancer who underwent SLNB under fluorescence endoscope by using ICG combined with blue dye dual-tracer method in Department of Breast Surgery,General Surgery Center,Zhujiang Hospital of Southern Medical University from April 2021 to August 2022 were retrospectively analyzed.The development of sentinel lymph node(SLN)and the development of metastatic SLN were compared in endoscopic fluorescence mode,high-definition white light mode,and fluorescence+white light dual-tracer mode.The detectable rates and the detectable number of SLN and metastatic SLN in the three modes were compared,and the tracer performance under endoscope in the three methods were analyzed.Results A total of 610 pieces of SLN were detected in the 166 patients,of whom 48 patients were detected with SLN metastasis,and endoscopic axillary lymph node dissection was performed on them,and a total of 95 pieces of metastatic SLN were detected.The detectable rate of SLN in the dual-tracer method group(98.19%)was significantly higher than that in the blue dye group(82.53%)(P<0.05),but there was no significant difference in the detectable rate of SLN between the dual-tracer method group(98.19%)and the ICG group(94.58%)(P>0.05).The number of SLN detected in the dual-tracer method group[(3.52±1.72)pieces]was significantly higher than that detected in the blue dye group[(1.95±1.68)pieces](P<0.05),but there was no significant difference in the number of SLN detected between the dual-tracer method group[(3.52±1.72)pieces]and the ICG group[(3.36±1.82)pieces](P>0.05).Conclusion The use of ICG combined with blue dye dual-tracer method in SLNB under fluorescence endoscope has higher detectable rate of SLN and more numbers of lymph nodes detected.

关 键 词：乳腺癌 前哨淋巴结活检 吲哚菁绿 荧光腔镜 

分 类 号：R737.9[医药卫生—肿瘤]