HMGB1、AQP4、8-OHdG、APN水平与癫痫患儿疾病进展及认知功能的关系  

Study on relationships between HMGB1,AQP4,8-OHdG,and APN levels and disease progression and cognitive function in children with epilepsy

作　　者：袁艳红 齐凤芹[2] 史静[1] 彭富栋[1] 王玉光 Yuan Yanhong;Qi Fengqin;Shi Jing;Peng Fudong;Wang Yuguang(Department of Neonatology,The Second People's Hospital of Liaocheng,Liaocheng 252600,China;Department of Pediatric Medicine,The Second People's Hospital of Liaocheng,Liaocheng 252600,China;Department of Pediatric Medicine,Liaocheng People's Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市第二人民医院新生儿科,聊城252600 [2]聊城市第二人民医院小儿内科,聊城252600 [3]聊城市人民医院小儿内科,聊城252000

出　　处：《国际医药卫生导报》2024年第22期3725-3730,共6页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技发展计划(2019WS104)。

摘　　要：目的探讨血清高迁移率族蛋白B1(HMGB1)、水通道蛋白4(AQP4)、8-羟基脱氧鸟苷(8-OHdG)、脂联素(APN)水平与癫痫患儿疾病进展及认知功能的关系。方法选取聊城市第二人民医院2021年1月至2023年12月收治的癫痫患儿142例为研究组,其中男74例,女68例,年龄(9.08±0.80)岁。根据癫痫类型分为全身强直阵挛发作组55例和局灶性发作组87例,并根据认知功能分为认知功能障碍组51例和认知功能正常组91例。另外选取同期接受健康体检的正常儿童145名为对照组。收集所选儿童的临床资料,均行血清HMGB1、AQP4、8-OHdG、APN水平检测,采用独立样本t检验比较研究组和对照组、不同癫痫类型及不同认知功能情况患儿血清HMGB1、AQP4、8-OHdG、APN水平,利用Pearson相关性分析癫痫患儿血清HMGB1、AQP4、8-OHdG、APN水平与认知功能的相关性,并绘制受试者操作特征曲线(ROC),获取曲线下面积(AUC),分析血清HMGB1、AQP4、8-OHdG、APN单独及联合检测对癫痫患儿认知功能障碍的预测价值。结果研究组血清HMGB1[(5.01±1.22)μg/L]、8-OHdG[(0.43±0.10)μg/L]水平高于对照组[(2.91±0.86)μg/L、(0.29±0.08)μg/L](均P<0.05),血清AQP4[(56.79±15.02)μg/L]、APN[(6.77±1.45)mg/L]水平低于对照组[(163.58±31.27)μg/L、(10.13±2.24)mg/L](均P<0.05)。全身强直阵挛发作组血清HMGB1[(6.14±1.98)μg/L]、8-OHdG[(0.53±0.15)μg/L]水平高于局灶性发作组[(3.95±1.10)μg/L、(0.36±0.09)μg/L](均P<0.05),血清AQP4[(41.43±12.07)μg/L]、APN[(4.64±1.40)mg/L]水平低于局灶性发作组[(70.89±21.44)μg/L、(7.98±2.32)mg/L](均P<0.05)。认知功能障碍组血清HMGB1[(6.18±2.04)μg/L]、8-OHdG[(0.57±0.19)μg/L]水平高于认知功能正常组[(3.98±1.25)μg/L、(0.38±0.12)μg/L](均P<0.05),血清AQP4[(46.94±15.15)μg/L]、APN[(4.97±1.55)mg/L]水平低于认知功能正常组[(71.43±23.59)μg/L、(8.01±2.53)mg/L](均P<0.05)。癫痫患儿血清HMGB1、8-OHdG水平与认知功能呈负相关(r=Objective To investigate the relationships between serum high mobility group protein B1(HMGB1),aquaporin 4(AQP4),8-hydroxydeoxyguanosine(8-OHdG),and adiponectin(APN)levels and disease progression and cognitive function in children with epilepsy.Methods A total of 142 children with epilepsy admitted to the Second People's Hospital of Liaocheng from January 2021 to December 2023 were selected as the study group,including 74 boys and 68 girls,aged(9.08±0.80)years.According to the type of epilepsy,they were divided into a general tonic-clonic seizure group(55 cases)and a focal seizure group(87 cases);they were divided into a cognitive dysfunction group(51 cases)and a normal cognitive function group(91 cases)according to the cognitive function.In addition,145 normal children who received health checkups during the same period were selected as the control group.The clinical data of the selected children were collected,and serum HMGB1,AQP4,8-OHdG,and APN levels were detected.Independent sample t test was used to compare serum HMGB1,AQP4,8-OHdG,and APN levels between the study group and the control group,as well as between children with different types of epilepsy and different cognitive functions.Pearson correlation analysis was used to analyze the correlations between serum HMGB1,AQP4,8-OHdG,and APN levels and cognitive function in children with epilepsy.The receiver operating characteristic curve(ROC)was plotted,and the area under the curve(AUC)was obtained.The predictive value of serum HMGB1,AQP4,8-OHdG,and APN alone and in combination for cognitive dysfunction in children with epilepsy was analyzed.Results The levels of serum HMGB1[(5.01±1.22)μg/L]and 8-OHdG[(0.43±0.10)μg/L]in the study group were higher than those in the control group[(2.91±0.86)μg/L and(0.29±0.08)μg/L](both P<0.05),but the levels of serum AQP4[(56.79±15.02)μg/L]and APN[(6.77±1.45)mg/L]were lower than those in the control group[(163.58±31.27)μg/L and(10.13±2.24)mg/L](both P<0.05).The levels of serum HMGB1[(6.14±1.98)μg/L]and 8-OHdG

关 键 词：癫痫 儿童 高迁移率族蛋白B1 水通道蛋白4 8-羟基脱氧鸟苷 脂联素 疾病进展 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]