miRNA⁃145调控胶质瘤恶性生物学行为研究进展  

Research progress on the regulation of malignant biological behavior of glioma by miRNA-145

作　　者：王军成 李欣龙[1] 马东明 潘亚文[3] WANG Jun-cheng;LI Xin-long;MA Dong-ming;PAN Ya-wen(The Second Clinical Medical School,Lanzhou University,Lanzhou 730030,Gansu,China;Department of Neurosurgery,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750001,Ningxia,China;Department of Neurosurgery,The Second Hospital,Lanzhou University,Institute of Neurology,Lanzhou University,Lanzhou 730030,Gansu,China)

机构地区：[1]兰州大学第二临床医学院,730030 [2]宁夏回族自治区人民医院神经外科,银川750001 [3]兰州大学第二医院神经外科兰州大学神经病学研究所,730030

出　　处：《中国现代神经疾病杂志》2024年第9期765-771,共7页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：宁夏回族自治区自然科学基金资助项目(项目编号:2021AAC03313);2021年第六批宁夏回族自治区青年科技人才托举工程;宁夏回族自治区银川市科技计划项目(项目编号:2023SF08);宁夏医科大学科学研究基金资助项目(项目编号:XM2020087);宁夏回族自治区人民医院国家自然科学基金预实验项目(项目编号:2021GZRYSY017)。

摘　　要：胶质瘤因其恶性增殖、侵袭、耐药性、免疫抑制等复杂的生物学特性,使临床治疗面临极大困难。尽管手术联合放化疗使患者生存率有一定提高,但总体疗效仍不显著。微小RNA(miRNA)作为一种非编码RNA,参与调控多种肿瘤(包括胶质瘤)的生物学过程,抑癌基因miRNA-145通过多种途径在胶质瘤发生与进展中发挥调控作用,尤其是作为靶向药物通过纳米载体运送至肿瘤区域治疗肿瘤成为当前研究热点。本文总结miRNA-145在胶质瘤病理分级、肿瘤微环境、胶质瘤干细胞调控、胶质瘤耐药性及胶质瘤预后中的作用,旨在为胶质瘤的诊断与治疗提供参考。Glioma is the most malignant brain tumor with high mortality.Due to its complex biological characteristics such as malignant proliferation,invasion,drug resistance,and immunosuppression,the clinical treatment faces great difficulties.Although the survival rate has improved under surgery combined with radiotherapy and chemotherapy,the overall curative effect is still not obvious.As a kind of non coding RNA(ncRNA),microRNA(miRNA)which has been extensively studied in recent years is involved in the regulation of biological processes of normal tissues and various tumors(including glioma)in human.As a cancer suppressor gene,miRNA-145 plays a regulatory role in the progression of glioma through a variety of pathways,especially as a targeted drug transported to the tumor area through nanocarriers to treat tumors,becoming a current research hotspot.This article summarizes the role of miRNA-145 in pathological grading,tumor microenvironment,the regulation of glioma stem cells,drug resistance,and the prognosis of glioma,aiming to provide the reference for the diagnosis and treatment of glioma.

关 键 词：神经胶质瘤 微RNAS 生物标记 综述 

分 类 号：R739.41[医药卫生—肿瘤]