基于多频段脑磁图技术的儿童失神癫痫神经网络研究  

Research on neural network in childhood absence epilepsy based on multi-frequency magnetoencephalography

作　　者：王英藩 杜明洋[1] 李明昊 卢婧 朱寅杰 王小姗[1] Wang Yingfan;Du Mingyang;Li Minghao;Lu Jing;Zhu Yinjie;Wang Xiaoshan(Department of Neurology,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院神经内科,南京210029

出　　处：《中华神经科杂志》2024年第10期1101-1110,共10页Chinese Journal of Neurology

基　　金：国家自然科学基金面上项目(82071455)。

摘　　要：目的应用多频段脑磁图技术探究儿童失神癫痫(CAE)患儿基于神经磁信号的网络连接和脑功能活动的改变。方法本研究为横断面研究,于2022年10月至2024年3月从南京医科大学附属脑科医院及南京医科大学附属儿童医院共招募25例初诊未服药的CAE患儿,并同期从社区招募25名年龄、性别相匹配的健康对照,使用CTF-275通道的脑磁图设备采集CAE患儿发作间期数据、发作期数据及健康对照数据。运用校正的振幅包络相关构建功能连接网络,并采用基于网络的统计方法比较组间网络差异。利用相对功率谱密度描述全脑频谱功率分布特征,采用重复1000次的非参数置换检验比较组间频谱功率差异。结果在功能连接方面,CAE患儿发作间期在低频段(δ、θ)观察到明显的网络活动增加,在δ频段可观察到一个包含默认模式网络关键节点的功能连接显著增高的子网络。与发作间期相比,CAE患儿失神发作期δ频段功能连接减弱,而中高频段(α-γ2)的网络连接增加。在频谱功率方面,CAE患儿发作间期在δ频段表现出广泛脑区的磁源激活,θ频段表现出顶叶、枕叶部分脑区的磁源激活,α-γ2频段顶枕颞叶大部分脑区磁源强度显著降低。与发作间期相比,CAE患儿失神发作期在δ频段表现出广泛脑区的磁源激活,θ-γ2频段的激活显著降低。根据磁源分布图,失神发作过程中α频段额叶的激活取代了顶枕区。结论在基于多频段神经磁信号的功能网络和频谱功率的分析中,发作间期的CAE患儿网络模式及磁源激活显著异于健康儿童,且在CAE患儿失神发作所致意识障碍期间神经磁信号存在特征性改变。ObjectiveTo investigate alterations in functional connectivity network and brain function activity in childhood absence epilepsy(CAE)based on neuromagnetic signals by using multi-frequency magnetoencephalography.MethodsTwenty-five drug-naive children diagnosed with CAE from the Affiliated Brain Hospital of Nanjing Medical University and the Affiliated Children′s Hospital of Nanjing Medical University during October 2022 and March 2024 and 25 healthy controls matched for age and sex from community were recruited in this cross-sectional study.The interictal data,ictal data of CAE and healthy control children were collected using a CTF-275 channel magnetoencephalography system.Corrected amplitude envelope correlation was used to construct functional connectivity network,and network-based statistics were used to compare network differences between groups.Relative power spectral density was used to describe the distribution characteristics of whole-brain spectral power.Nonparametric permutation tests were conducted 1000 times to compare spectral power differences between groups.ResultsIn terms of functional connectivity,significant increases in network activity were observed in the low-frequency bands(δ,θ)during interictal periods in children with CAE.A sub-network with significantly increased functional connectivity,including key nodes of the default mode network,was observed in theδband.Compared with interictal periods,functional connectivity in theδband decreased during absence seizures in children with CAE,while connectivity in the mid-to-high-frequency bands(α-γ2)increased.In terms of spectral power,children with CAE during interictal periods exhibited widespread magnetic source activation in theδband,activation in parts of the parietal and occipital lobes in theθband,and significantly decreased magnetic source intensity in most areas of the parietal,occipital,and temporal lobes in theα-γ2 band.Compared with interictal periods,children with CAE during absence seizures exhibited widespread magnetic sou

关 键 词：癫痫 失神性 儿童 脑磁图描记术 多频段 功能连接 频谱功率 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]