基于铁死亡的肾癌治疗药物研究进展  

Research progress of kidney cancer treatment drugs based on ferroptosis

作　　者：余灵艳 阳馨仪 杨陈 杜璟 张隽瑜 童向民[2,3,4] YU Lingyan;YANG Xinyi;YANG Chen;DU Jing;ZHANG Juanyu;TONG Xiangmin(The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Zhejiang Hangzhou 310053,China;Zhejiang Provincial People's Hospital(Hangzhou Medical College Affiliated People's Hospital)Laboratory Center,Zhejiang Hangzhou 310014,China;West Lake University Affiliated Hangzhou First People's Hospital,Zhejiang Hangzhou 310006,China;Department of Hematology,Lishui Central Hospital,Zhejiang Lishui 323000,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江省人民医院(杭州医学院附属人民医院)检验中心,浙江杭州310014 [3]西湖大学附属杭州市第一人民医院,浙江杭州310006 [4]丽水市中心医院血液科,浙江丽水323000

出　　处：《现代肿瘤医学》2024年第21期4167-4172,共6页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:82102938)。

摘　　要：肾癌是泌尿系统常见的恶性肿瘤,严重威胁着人体健康。手术是目前治疗早期肾癌的有效策略,但由于晚期肾癌化疗效果差,易发生耐药,因此迫切需要开发其他潜在的治疗策略。铁死亡是一种新定义的程序性细胞死亡形式,特征是铁依赖性脂质过氧化物的积累,在肿瘤进展和耐药性中起关键作用。研究表明,铁死亡参与肾癌的发生发展,铁死亡相关基因可诱导细胞凋亡,作为肾癌早期诊断的潜在生物标志物并参与肾癌化疗的耐药。随着铁死亡机制的完善,靶向铁死亡治疗肾癌的药物层出不穷。因此该文结合铁死亡发生机制的理论基础,从中草药、天然化合物、耐药机制、纳米材料等方面对药物诱导肾癌细胞铁死亡进行综述,希望为铁死亡相关药物治疗肾癌提供新策略。Kidney cancer is a common malignant tumor of the urinary system,which is a serious threat to human health.Surgery is an effective strategy for the treatment of early-stage kidney cancer.However,due to the poor treatment effect of advanced renal cancer and the susceptibility of chemotherapy to drug resistance,there is an urgent need to develop other potential therapeutic strategies.Ferroptosis is a newly defined form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides,which plays a critical role in tumor progression and drug resistance.Recent studies have shown that ferroptosis is involved in the occurrence and development of kidney cancer.Ferroptosis related genes can induce cell apoptosis,and can be used as potential biomarkers for early diagnosis of renal cancer and participate in drug resistance of renal cancer chemotherapy.With the continuous improvement of the mechanism of ferroptosis,drugs targeting ferroptosis for the treatment of renal cancer are emerging in an endless stream.Based on the theoretical basis of the occurrence of ferroptosis,this paper reviewes drug-induced ferroptosis in renal cancer cells from the aspects of herbal medicine,natural compounds,drug resistance mechanisms,and nanomaterials,hoping to provide a new strategy for the treatment of renal cancer with ferroptosis related drugs.

关 键 词：铁死亡 肾癌 中草药 天然化合物 纳米材料 

分 类 号：R737.11[医药卫生—肿瘤]