棕色脂肪组织调控能量代谢及其对肿瘤影响的研究进展  

Research progress on the effects of brown adipose tissue-regulated energy metabolism on tumor

作　　者：裴蓉蓉 陈晓琦[1] 赵晴 张传雷[1] 王新亭[1] 袁长威 杨芳明[1] 陈欣菊[1] PEI Rongrong;CHEN Xiaoqi;ZHAO Qing;ZHANG Chuanlei;WANG Xinting;YUAN Changwei;YANG Fangming;CHEN Xinju(Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital,Henan University of Traditional Chinese Medicine,Henan Zhengzhou 450000,China;The First Clinical Medical College,Henan University of Chinese Medicine,Henan Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院脾胃肝胆科,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450000

出　　处：《现代肿瘤医学》2024年第21期4200-4205,共6页Journal of Modern Oncology

基　　金：河南省自然科学基金项目(编号:242300421298)。

摘　　要：能量代谢重编程是肿瘤细胞的重要生物学特征,肿瘤通过异常糖酵解和增强的脂肪酸合成等代谢方式为其生长增殖提供能量。棕色脂肪活化摄取葡萄糖和游离脂肪酸,在肿瘤的生长增殖中形成代谢竞争,从而抑制肿瘤的生长,但在高代谢的恶病质时期会加速恶病质的进展。该文综述了棕色脂肪组织在能量代谢中的作用及其对肿瘤的影响,以期为恶性肿瘤或恶病质的治疗提供新的思路。Reprogramming of energy metabolism is an important biological feature of tumor cells,which provides energy for tumor growth and proliferation through metabolic methods such as abnormal glycolysis and enhanced fatty acid synthesis.Brown adipose activation uptake of glucose and free fatty acids creates metabolic competition in tumor growth and proliferation,which inhibits tumor growth but accelerates malignant progression during periods of hypermetabolic malignancy.This article reviews the role of brown adipose tissue in energy metabolism and its effects on tumors,with a view to providing new ideas for the treatment of malignant tumors or cachexia.

关 键 词：棕色脂肪组织 肿瘤代谢 研究进展 

分 类 号：R730[医药卫生—肿瘤]