IL-6R mRNA水平与双相情感障碍主客观睡眠的相关性研究  

Correlation study of IL-6R mRNA levels and subjective and objective sleep in bipolar disorder

作　　者：潘友让 冯虹 PAN Yourang;FENG Hong(Department of Psychiatry,the Seventh People’s Hospital of Shaoxing City,Shaoxing 312000,Zhejiang,China)

机构地区：[1]绍兴市第七人民医院精神科,浙江绍兴312000

出　　处：《中国现代医生》2024年第30期24-28,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2022RC279,2023RC292)。

摘　　要：目的探讨双相情感障碍患者外周血中单核细胞白细胞介素-6受体mRNA(interleukin-6 receptor mRNA,IL-6R mRNA)水平与其主客观睡眠的相关性。方法采用病例对照研究,选取绍兴市第七人民医院2022年6月至2023年6月精神科门诊确诊的25例双相情感障碍患者作为病例组,选取同期25名无精神疾病的门诊健康体检者作为对照组。采用匹兹堡睡眠质量指数量表(Pittsburgh sleep quality index scale,PSQI)、多导睡眠图(polysomnography,PSG)评估检测两组纳入者的睡眠质量,并分析与IL-6R mRNA的相关性。结果病例组患者的外周血IL-6R mRNA与睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物使用情况、日间功能及PSQI总分均呈显著正相关(P<0.05),与睡眠总时间、睡眠效率、熟睡时间、快速动眼睡眠时间均呈负相关(P<0.01),与觉醒时间呈正相关关系(P<0.05)。结论双相情感障碍患者外周血中单核细胞IL-6R mRNA水平显著升高且与患者的主客观睡眠质量降低密切相关。Objective To explore the correlation between the levels of interleukin-6 receptor mRNA(IL-6R mRNA)in peripheral blood of patients with bipolar disorder and their subjective and objective sleep conditions.Methods By using the case-control study,25 cases of bipolar disorder patients diagnosed by psychiatric clinic of the Seventh People’s Hospital of Shaoxing City from June 2022 to June 2023 were selected case group,25 volunteers with outpatient health examination without mental illness were selected as control group.Pittsburgh sleep quality index scale(PSQI)and polysomnography(PSG)were used to evaluate the sleep quality of two groups,and respectively analyzed the correlation with the IL-6R mRNA levels of case group.Results In case group,the peripheral blood IL-6R mRNA was positively correlated with sleep quality,time to fall asleep,sleep time,sleep efficiency,sleep disorder,use of hypnotic drugs,daytime function and PSQI total score(P<0.05),and total sleep time,sleep efficiency,time of deep sleep,rapid eye movement sleep time were negatively associated(P<0.01),and the peripheral blood IL-6R mRNA was positively associated with awakening time of patients(P<0.05).Conclusion The level of IL-6R mRNA in monocytes in peripheral blood of patients with bipolar disorder significantly increases,and is closely related to the decrease in subjective and objective sleep quality of patients.

关 键 词：双相情感障碍 单核细胞 白细胞介素-6受体 睡眠质量 匹兹堡睡眠质量指数量表 多导睡眠图 

分 类 号：R749.91[医药卫生—神经病学与精神病学]