高甘油三酯血症性急性胰腺炎患者临床特征及血清铁蛋白、C反应蛋白、肌酐水平  

Clinical characteristics and serum ferritin,C-reactive protein and creatinine levels in patients with hypertriglyceridemia induced acute pancreatitis

作　　者：罗杰 谈冰 汪慧 徐玉龙 LUO Jie;TAN Bing;WANG Hui;XU Yulong(Department of Emergency,Anhui Provincial Second People′s Hospital,Hefei,Anhui 230000,China)

机构地区：[1]安徽省第二人民医院急诊科,安徽合肥230000

出　　处：《检验医学与临床》2024年第21期3132-3136,共5页Laboratory Medicine and Clinic

基　　金：安徽省卫生和计划生育委员会科研计划项目(2018SEYL018)。

摘　　要：目的探讨高甘油三酯血症性急性胰腺炎(HLAP)患者的临床特征,以及血清铁蛋白、C反应蛋白(CRP)、肌酐水平及其意义。方法采用病例对照研究方法,选取该院急诊科2021年1月至2022年3月确诊的96例HLAP患者作为HLAP组,选取同期确诊的其他类型急性胰腺炎患者93例作为对照组(胆源性急性胰腺炎47例、酒精性急性胰腺炎46例),选取健康体检志愿者90例作为健康组,对比3组的人口学特征、临床特点、血脂等指标,并分析不同病情程度HLAP患者血清铁蛋白、CRP、肌酐水平。结果HLAP组的体质量指数(BMI)、白细胞计数(WBC)、甘油三酯(TG)、男性患者占比高于对照组和健康组,丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、淀粉酶(AMS)、D-二聚体(D-D)水平低于对照组,差异均有统计学意义(P<0.05)。HLAP组的年龄小于健康组、对照组,ALT、AST、AMS、D-D水平高于健康组,差异均有统计学意义(P<0.05)。对照组的WBC、ALT、AST、AMS、D-D水平高于健康组,差异均有统计学意义(P<0.05)。HLAP组的急性生理与慢性健康状况评分Ⅱ(APACHEⅡ评分)、改良CT严重指数(MCTSI)、急性胰腺炎严重程度床边评分(BISAP评分)高于对照组,差异均有统计学意义(P<0.05);HLAP组中度及重度患者占比、全身炎症反应综合征患者占比、器官衰竭患者占比均高于对照组,差异均有统计学意义(P<0.05);HLAP组血清铁蛋白、CRP、肌酐水平均高于对照组和健康组,差异均有统计学意义(P<0.05);对照组血清铁蛋白、CRP、肌酐水平均高于健康组,差异均有统计学意义(P<0.05);中度及重度HLAP患者血清铁蛋白、CRP、肌酐水平均高于轻度HLAP患者,差异均有统计学意义(P<0.05)。结论相对于胆源性急性胰腺炎或酒精性急性胰腺炎患者,HLAP患者发病年龄更低,病情一般更为严重,血清铁蛋白、CRP、肌酐水平更高。Objective To investigate the clinical characteristics of patients with hypertriglyceridemia-induced acute pancreatitis(HLAP)and analyze serum ferritin,C-reactive protein(CRP)and creatinine levels and their significance.Methods A case-control study was conducted by selecting 96 patients with HLAP diagnosed at the Department of Emergency of the hospital from January 2021 to March 2022 as the HLAP group.For comparison,93 patients with other types of acute pancreatitis diagnosed during the same period were included as the control group(47 with biliary acute pancreatitis and 46 with alcoholic acute pancreatitis).Additionally,90 healthy volunteers were selected as the healthy group.The demographic characteristics,clinical features,lipid and other indexes were compared among the three groups,serum ferritin,CRP and creatinine levels were analyzed in HLAP patients with different severity.Results The body mass index(BMI),white blood cell count(WBC),triglyceride(TG)level and the proportion of male patients in the HLAP group were significantly higher than those in the control group and healthy group,and the differences were statistically significant(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),amylase(AMS)and D-dimer(D-D)were lower in the HLAP group compared with the control group,and the differences were statistically significant(P<0.05).The patients in the HLAP group were younger than those in the healthy group and the control group,while ALT,AST,AMS and D-D levels were higher than those in the healthy group,and the differences were statistically significant(P<0.05).In the control group,the levels of WBC,ALT,AST,AMS and D-D were higher than those of the healthy group,and the differences were statistically significant(P<0.05).The Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)score,Modified CT Severity Index(MCTSI)and Bedside Index for Severity in Acute Pancreatitis(BISAP)scores in the HLAP group were higher than those in the control group,and the differences were statisti

关 键 词：高甘油三酯血症 急性胰腺炎 临床特征 铁蛋白 C反应蛋白 肌酐 

分 类 号：R576[医药卫生—消化系统] R446.11[医药卫生—内科学]