MECT治疗对重度抑郁发作患者脑电波及HAMD评分的影响  

Effect of MECT treatment on EEG waves and HAMD scores in patients with severe depressive episodes

作　　者：庄二阳 刘绪蓬 陈旋 孟俊廷 ZHUANG Eryang;LIU Xupeng;CHEN Xuan;MENG Junting(Second Department of Psychology;EEG Room,Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University,Xuzhou,Jiangsu 221004,China)

机构地区：[1]徐州医科大学附属徐州东方医院心理二科,江苏徐州221004 [2]徐州医科大学附属徐州东方医院脑电图室,江苏徐州221004

出　　处：《检验医学与临床》2024年第21期3225-3228,3233,共5页Laboratory Medicine and Clinic

基　　金：江苏省徐州市卫生健康委员会科技面上项目(XWKYHT20210554)。

摘　　要：目的探讨改良无抽搐电休克疗法(MECT)治疗对重度抑郁发作患者脑电波及汉密尔顿抑郁量表(HAMD)评分的影响。方法以2021年5月至2022年12月在徐州医科大学附属徐州东方医院诊断为重度抑郁发作的120例住院患者作为研究对象,随机分为观察组、对照组,每组60例。对照组仅给予药物治疗,观察组患者在药物治疗的基础上同时给予MECT治疗。比较两组治疗效果,以及前额脑电波功率、HAMD评分的差异;分析观察组患者治疗后前额脑电波功率与HAMD评分的相关性;比较两组的不良反应发生情况。结果观察组治疗总有效率(96.67%)高于对照组(86.67%),差异有统计学意义(P<0.05)。治疗前,两组的左前额、右前额的脑电波功率及HAMD评分比较,差异均无统计学意义(P>0.05);治疗后,观察组左前额、右前额的α1波功率高于对照组(P<0.05),δ、θ波功率以及HAMD评分均明显低于对照组(P<0.05)。相关性分析结果显示,观察组患者治疗后左前额、右前额的α1波功率与HAMD评分呈负相关(P<0.05)、δ、θ波功率与HAMD评分均呈正相关(P<0.001)。治疗期间两组患者口干、恶心呕吐、厌食、视力模糊的发生率比较,差异均无统计学意义(P>0.05)。结论MECT与抗抑郁药物联用治疗重度抑郁发作效果确切,且治疗后脑电波功率与HAMD评分相关。Objective To explore the effects of modified convulsive electroconvulsive therapy(MECT)on brainwaves and Hamilton Depression Rating Scale(HAMD)scores in patients with depressive episodes.Methods A total of 120 hospitalized patients diagnosed with severe depressive episodes at Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University from May 2021 to December 2022 were selected as study subjects and divided into the observation group and the control group,with 60 patients in each group.The control group only received medication treatment,while the observation group received MECT treatment on the basis of medication treatment.The therapeutic effects between the two groups were compared,as well as the differences in prefrontal electroencephalogram(EEG)power and HAMD scores;the correlation between frontal EEG power and HAMD scores of patients in the observation group after treatment was compared;the occurrence of adverse reactions between the two groups were compared.Results The total effective rate of the observation group(96.67%)was higher than that of the control group(86.67%),and the difference was statistically significant(P<0.05).Comparison of the left prefrontal and right prefrontal EEG power and HAMD scores of the two groups before treatment showed no statistically significant differences(P>0.05).After treatment,the left prefrontal and right prefrontalα1 wave power of the observation group was significantly higher than that of the control group(P<0.05),δ,θwave power and HAMD scores of the observation group were significantly lower than those of the control group(P<0.05).Correlation analysis results showed that the left prefrontal and right prefrontalα1 wave power of the patients in the observation group were negatively correlated with HAMD scores after treatment(P<0.001),δ,θwave power of the patients in the observation group were positively correlated with HAMD scores after treatment(P<0.001).There were no statistically significant differences in the incidences of dry mouth,nausea and vomiting,an

关 键 词：抑郁发作 改良无抽搐电休克疗法 汉密尔顿抑郁量表评分 脑电波 脑电图 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445.9[医药卫生—临床医学]