脉络通颗粒治疗急性丘脑梗死所致认知障碍的临床研究  

Clinical Study of Mailuotong Granules for Cognitive Impairment Caused by Acute Thalamic Infarction

作　　者：陈瑞芳 付静 赵松耀 李世泽 CHEN Rui-fang;FU Jing;ZHAO Song-yao;LI Shi-ze(Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)

机构地区：[1]郑州大学附属郑州中心医院神经内科,郑州450007

出　　处：《中国合理用药探索》2024年第10期74-78,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:探讨脉络通颗粒治疗急性丘脑梗死所致认知障碍的临床疗效及对患者炎症因子的影响。方法:选取2018年11月~2024年5月期间于某院住院治疗的62例急性丘脑梗死所致认知障碍患者作为研究对象,采用随机数字表法分为对照组和观察组,每组31例。对照组患者给予抗血小板聚集及他汀类药物等常规治疗,观察组患者在对照组治疗基础上口服脉络通颗粒。比较两组患者认知功能[蒙特利尔认知评估量表(MoCA)]、血清炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和超敏C反应蛋白(hs-CRP)]及不良反应发生情况。结果:治疗3个月后,观察组患者视空间与执行、注意力、延迟回忆、时间/空间定向力测试得分及MoCA总分均高于对照组(P<0.05);两组患者血清TNF-α、IL-6和hs-CRP水平均降低,且观察组低于对照组(P<0.05)。治疗期间,两组患者不良反应总发生率比较无统计学差异(P>0.05)。结论:脉络通颗粒治疗急性丘脑梗死所致认知障碍患者临床疗效较佳,可有效改善患者认知功能,减轻炎症反应,且未增加不良反应的发生风险。Objective:To investigate the clinical efficacy of Mailuotong granules in the treatment of cognitive impairment caused by acute thalamic infarction and its effect on inflammatory factors.Methods:A total of 62 patients with cognitive impairment after acute thalamic infarction who were admitted to a certain hospital from November 2018 to May 2024 were selected and divided into the control group and observation group by random number table method,with 31 patients in each group.The control group was given conventional treatment including antiplatelet aggregation and statins,and the observation group was given Mailuotong granules in addition to the control treatment.The cognitive function[Montreal cognitive assessment(MoCA)],serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C reactive protein(hs-CRP)]and adverse reactions were compared between the two groups.Results:After 3 months of treatment,the scores of visuospatial and executive function,attention,delayed recall,time/space orientation and the total score of MoCA in the observation group were higher than those in the control group(P<0.05).The serum levels of TNF-α,IL-6 and hs-CRP were decreased in both groups,and lower in the observation group compared with the control group(P<0.05).During the treatment period,no statistically significant difference was observed in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Mailuotong granules exhibited satisfactory clinical efficacy in the treatment of cognitive impairment caused by acute thalamic infarction as demonstrated by effectively improved cognitive function and reduced inflammatory response,with no additional risks of adverse reactions.

关 键 词：脉络通颗粒 丘脑梗死 认知障碍 临床疗效 炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]