基质细胞衍生因子1及C-X-C趋化因子受体4和7信号通路在脉络膜新生血管疾病进展中的作用  

The roles of stromal cell-derived factor-1/C-X-C chemokine receptor type 4/C-X-C chemokine receptor type 7 signaling in choroidal neovascularization progression

作　　者：邹蓉 袁非 Zou Rong;Yuan Fei(Department of Ophthalmology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院眼科,上海200032

出　　处：《国际眼科纵览》2024年第5期341-348,共8页International Review of Ophthalmology

摘　　要：脉络膜新生血管(choroidal neovascularization,CNV)是新生血管性年龄相关性黄斑变性(neovascular age-related macular degeneration,NVAMD)患者致盲的重要病理改变。调控血管新生的关键分子血管内皮生长因子A通过与其酪氨酸激酶受体结合不仅介导眼正常发育过程中毛细血管丛的定位和结构的重塑,还促进病理性的血管新生和渗漏。而近来的研究明确了另一重要分子基质细胞衍生因子1(stromal cell-derived factor-1,SDF-1)通过与其C-X-C趋化因子受体(C-X-C chemokine receptor type,CXCR)4和CXCR7结合,介导内皮祖细胞、巨噬细胞等免疫细胞的趋化作用,通过直接激活内皮细胞中PI3K/AKT/ERK等信号通路,促进内皮细胞增殖、迁移和成管,进而调控病理性脉络膜新生血管的进展,并诱导内皮细胞发生间质化变促进视网膜下纤维化。Choroidal neovascularization(CNV)is an important pathological mechanism of blinding neovascular age-related macular degeneration(NVAMD).Vascular endothelial growth factor(VEGFA),the key regulator of angiogenesis,not only mediates the localization and structural remodeling of the capillary plexus during normal eye development by binding to its tyrosine kinase receptor,but also promotes pathological angiogenesis and leakage.Recent studies has proved that stromal cell-derived factor-1(SDF-1)mediates the chemotaxis of immune cells such as endothelial progenitor cells and macrophages by binding to its C-X-C chemokine receptor type(CXCR)4 and CXCR7.It also directly activates signaling pathways such as PI3K/AKT/ERK in endothelial cells to promote endothelial cell proliferation,migration,and angiogenesis,thereby regulating the development of pathological choroidal neovascularization and induces endothelial-to-mesenchymal transition of endothelial cells(EndoMT)to promote subretinal fibrosis.

关 键 词：脉络膜新生血管 基质细胞衍生因子1 C-X-C趋化因子受体4 C-X-C趋化因子受体7 

分 类 号：R773.4[医药卫生—眼科]