前房相关性免疫偏离的研究进展  

Research progress of anterior chamber-associated deviation

作　　者：李谦 卿国平 Li Qian;Qing Guoping(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University/Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,北京100730

出　　处：《国际眼科纵览》2024年第5期364-370,共7页International Review of Ophthalmology

摘　　要：前房相关性免疫偏离(anterior chamber-associated immune deviation,ACAID)是眼部免疫赦免的主要表现形式,主要涉及抗原提呈细胞和调节性T细胞的作用,以抑制对眼内抗原的全身性免疫应答。其内在机制复杂,不仅依赖于眼球的正常解剖结构和生理功能,还涉及动态的免疫调节过程和体液平衡。近年来的研究揭示了更多与ACAID相关的分子机制,如免疫检查点分子的作用及其对免疫耐受的影响。此外,ACAID机制的研究还表明其在防止移植物排斥和治疗自身免疫性眼病中的潜在应用价值。这些研究成果为理解眼部免疫赦免的过程提供了新的视角,并对开发新的抗炎和免疫治疗方法具有重要意义。Anterior chamber-associated immune deviation(ACAID)is the primary manifestation of ocular immune privilege.It mainly involves the roles of antigen-presenting cells and regulatory T cells to inhibit systemic immune responses against intraocular antigens.The underlying mechanisms are complex,relying not only on the normal anatomical structure and physiological functions of the eye but also involving dynamic immune regulatory processes and humoral balance.Recent research has revealed more molecular mechanisms related to ACAID,such as the roles of immune checkpoint molecules and their impact on immune tolerance.Moreover,studies of ACAID mechanisms have demonstrated its potential applications in preventing graft rejection and treating autoimmune eye diseases.These research findings provide new perspectives on understanding the process of ocular immune privilege and are of significant importance in developing novel anti-inflammatory and immunotherapeutic approaches.

关 键 词：前房相关性免疫偏离 免疫赦免 免疫抑制微环境 调节性T细胞 

分 类 号：R77[医药卫生—眼科]