Comparative study between swept-source and spectraldomain OCTA for imaging of choroidal neovascularization in age-related macular degeneration  

作　　者：Ji-Xian Ma Zhuo-Yi Zhang Rong Di Jia-Jie Yang Si-Wen Tian Ya-Zhou Qin Wan-Hu Zhang Jian-Qin Lei Qiu-Ping Liu Jing-Ming Li 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China [2]Affiliated Eye Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [3]Department of Ophthalmology,First Affiliated Hospital of Nanhua University,Hengyang 421005,Hunan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第11期2067-2073,共7页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China(No.82271098;No.81960177);Key Research and Development Program of Shaanxi Province(2024SF-YBXM-322);Institutional Foundation of the First Affiliated Hospital of Xi’an Jiaotong University(No.2021ZXY-10).

摘　　要：AIM:To compare the dif ferences of choroidal neovascularization(CNV)measurements between sweptsource and spectral-domain optical coherence tomography angiography(SS-OCTA and SD-OCTA)in neovascular agerelated macular degeneration(nAMD)and the imaging reliability of the two devices.METHODS:Prospective comparative study.SS-OCTA and SD-OCTA were used to scan the same eye with the modes of 3×3 and 6×6 mm2 centered on the neovascularization.Only qualified images were chosen and the border of CNV was manually delineated by two graders independently.The area of CNV(ACNV),vascular perfusion density(PD),and vessel length density(VLD)within the delineation were calculated using Image J.The differences of CNV measurements between the two OCTA devices were compared using Bland-Altman analysis.The agreement between the two graders on the measurements of each device was compared using the intraclass correlation coefficient(ICC).RESULTS:A total of 18 patients(22 eyes)with nAMD were included.The measurements of ACNV,PD,and VLD were 7.247±4.586 and 4.901±3.741 mm^(2),43.202±9.636 and 34.904±10.489,6.339±1.228 and 5.908±1.741 mm^(-1) for SS-OCTA and SD-OCTA,respectively.The differences between the two devices were 2.346±3.030 mm^(2)(Z=-3.782,P<0.0001),8.298±14.160(Z=-2.419,P=0.016),and 0.431±2.114 mm^(-1)(Z=-0.828,P=0.408)for ACNV,PD and VLD,respectively.The ICC between two graders were 0.893(P<0.001),0.902(P<0.001),0.885(P<0.001)for ACNV,PD,VLD in SS-OCTA,and 0.971(P<0.001),0.976(P<0.001),0.973(P<0.001)in SD-OCTA,respectively.CONCLUSION:Both OCTA devices have high imaging reliability.Compared with SD-OCTA,SS-OCTA has a larger ACNV measurements,but doesn’t show better resolution of internal vessels of CNV and well signal strength.

关 键 词：neovascular age-related macular degeneration swept-source SPECTRAL-DOMAIN optical coherence tomography angiography 

分 类 号：R774.5[医药卫生—眼科]