miR-137基因多态性与妊娠期糖尿病遗传易感性的相关性  

Association of miR-137 gene polymorphisms with genetic susceptibility to gestational diabetes mellitus

作　　者：黄宏超 熊新华 刘桂芳 魏文峰 苏晓彤 欧阳昭 卢慧诗 Huang Hongchao;Xiong Xinhua;Liu Guifang;Wei Wenfeng;Su Xiaotong;Ouyang Zhao;Lu Huishi(Department of Internal Medicine,Shunde Women and Childrens Hospital of Guangdong Medical University(Foshan Maternal and Child Health Hospital),Foshan 528300,China;Guangdong Tongjiang Hospital Physical Examination Center,Foshan 528300,China;Department of Obstetrical,Shunde Women and Childrens Hospital of Guangdong Medical University(Foshan Maternal and Child Health Hospital),Foshan 528300,China)

机构地区：[1]广东医科大学顺德妇女儿童医院(佛山市顺德区妇幼保健院)内科,佛山528300 [2]广东同江医院体检中心,佛山528300 [3]广东医科大学顺德妇女儿童医院(佛山市顺德区妇幼保健院)产科,佛山528300

出　　处：《中国医师杂志》2024年第10期1509-1513,共5页Journal of Chinese Physician

基　　金：广东省中医药局医学科研项目(20231319);2022年佛山市自筹经费类科技创新项目入库培育项目(2220001004532)。

摘　　要：目的探讨miR-137基因多态性与妊娠期糖尿病遗传易感性的相关性。方法选取2023年1月至2023年9月在广东医科大学顺德妇女儿童医院就诊的妊娠期糖尿病孕妇500例作为观察组,同时选取糖代谢正常且无妊娠并发症的健康孕妇500例作为对照组,采用聚合酶链反应技术检测两组miR-137基因rs1625579位点多态性,同时比较两组孕妇临床资料差异,分析妊娠期糖尿病发生的影响因素。结果观察组miR-137基因rs1625579位点GT+GG基因型、等位基因G频率分别为13.20%和7.00%,明显高于对照组(均P<0.05)。观察组miR-137基因型GT+GG孕妇空腹血糖(FPG)、空腹胰岛素(FINS)和胰岛素抵抗指数(HOMA-IR)分别为(7.92±0.81)mmol/L、(19.92±3.10)mmol/L和6.60±1.02,明显高于基因型TT孕妇(均P<0.05),而胰岛β细胞功能指数(HOMA-β)为188.84±43.34,明显低于基因型TT孕妇(P<0.05)。观察组孕前BMI、孕期每周平均增重分别为(23.81±1.92)kg/m2和(445.50±35.65)g,明显高于对照组(均P<0.05);观察组有糖尿病家族史比例为8.60%,明显高于对照组(P<0.05)。Logistic回归分析显示:孕前BMI和孕期每周平均增重是妊娠期糖尿病发生的影响因素(均P<0.05)。结论妊娠期糖尿病发生与miR-137基因多态性无明显相关性,而与孕前BMI和孕期每周平均增重有关;较其他miR-137基因型患者,GT+GG患者更易发生血糖异常情况。Objective To investigate the correlation between miR-137 gene polymorphism and genetic susceptibility to gestational diabetes mellitus.Methods sA total of 500 pregnant women with gestational diabetes who were admitted to Shunde Women and Childrens Hospital of Guangdong Medical University from January 2023 to September 2023 were selected as the observation group,and 500 healthy pregnant women with normal glucose metabolism and no pregnancy complications were selected as the control group.Polymerase chain reaction(PCR)was used to detect rs1625579 polymorphisms of miR-137 gene between the two groups,and the clinical data of the two groups were compared to analyze the influencing factors of the occurrence of gestational diabetes mellitus.Results The frequencies of GT+GG genotype and allele G at rs1625579 site of miR-137 gene in observation group were 13.20%and 7.00%,respectively,which were significantly higher than those in control group(all P<0.05).Fasting blood glucose(FPG),fasting insulin(FINS)and insulin resistance index(HOMA-IR)of miR-137 genotype GT+GG pregnant women in the observation group were(7.92±0.81)mmol/L,(19.92±3.10)mmol/L and 6.60±1.02,respectively.It was significantly higher than genotypic TT pregnant women(all P<0.05),and isletβcell function index(HOMA-β)was significantly lower than genotypic TT pregnant women(188.84±43.34)(P<0.05).Pre-pregnancy body mass index(BMI)and average weekly weight gain during pregnancy in the observation group were(23.81±1.92)kg/m²and(445.50±35.65)g,respectively,which were significantly higher than those in the control group(all P<0.05).The proportion of family history of diabetes in the observation group was 8.60%,which was significantly higher than that in the control group(P<0.05).Logistic regression analysis showed that preconception BMI and average weekly weight gain during pregnancy were the influential factors for the occurrence of gestational diabetes(all P<0.05).Conclusions The occurrence of gestational diabetes mellitus has no significant correlation wit

关 键 词：糖尿病 妊娠 miR-137 多态性 单核苷酸 疾病遗传易感性 

分 类 号：R714.256[医药卫生—妇产科学]