基质金属蛋白酶在肝纤维化中的应用研究进展  

Research progress of application of matrix metalloproteinases in hepatic fibrosis

作　　者：万学娜 袁会成 杨凯 赵良存 胥少华 WAN Xuena;YUAN Huicheng;YANG Kai;ZHAO Liangcun;XU Shaohua(Department of Pharmacy,Gansu Wuwei Tumour Hospital,Gansu Province,Wuwei 733000,China)

机构地区：[1]甘肃省武威肿瘤医院药学部,甘肃武威733000

出　　处：《中国当代医药》2024年第29期185-192,共8页China Modern Medicine

基　　金：甘肃省武威市市列科技计划项目(WW2101138)。

摘　　要：肝纤维化(HF)是肝脏慢性疾病的常见并发症,严重影响患者生活质量,甚至威胁患者生命。其复杂的发病机制包括持续氧化导致的肝实质损伤、免疫细胞的激活和募集、肝星状细胞(HSC)的激活以及纤维化细胞外基质(ECM)成分的合成导致瘢痕形成。临床研究和动物模型表明,纤维化是可逆的。本文综述了基质金属蛋白(MMPs)及组织金属蛋白酶抑制剂(TIMPs)在HF中的作用机制,发现MMPs因其在纤维化和再生过程中调节组织周转的能力而成为治疗靶点,它们通过影响细胞行为,如增殖、基因表达和凋亡,进而影响纤维化和再生。本文旨在总结和更新有关MMPs在HF中的表达模式和中心作用的研究进展,为未来进一步深入研究其机制及HF的治疗提供参考。Hepatic fibrosis(HF)is a common complication of chronic liver diseases,which seriously affects the quality of life of patients and even threatens their lives.Its complex pathogenesis includes liver parenchymal injury due to continuous oxidation,activation and recruitment of immune cells,activation of hepatic stellate cell(HSC),and synthesis of extracellular matrix(ECM)components leading to scarring.Clinical studies and animal models have shown that fibrosis is reversible.In this paper,we review the mechanism of action of matrix metalloproteinases(MMPs)and tissue inhibitor of matrix metallo-proteinases(TIMPs)in HF,and find that MMPs are therapeutic targets due to their ability to regulate tissue turnover during fibrosis and regeneration,and they influence fibrosis and regeneration by influencing cell behavior,such as proliferation,gene expression,and apoptosis.This paper aims to summarize and update the research progress on the expression pattern and central role of MMPs in HF,so as to provide reference for further research on its mechanism and treatment of HF in the future.

关 键 词：肝纤维化 基质金属蛋白酶 基质金属蛋白酶抑制剂 肝星状细胞 细胞外基质 

分 类 号：R575.2[医药卫生—消化系统]