静脉溶栓联合介入治疗应用于急性脑梗死患者的临床效果  

Clinical Effects of Intravenous Thrombolysis Combine with Interventional Therapy in Patients with Acute Cerebral Infarction

作　　者：李小虎 赵玉莲 LI Xiaohu;ZHAO Yulian(Qitai Hospital of the Sixth Division of Xinjiang Production and Construction Corps,Changji,Xinjiang Uygur Autono-mous Region,831800,China)

机构地区：[1]新疆生产建设兵团第六师奇台医院,新疆维吾尔自治区昌吉831800

出　　处：《中外医疗》2024年第25期1-4,共4页China & Foreign Medical Treatment

基　　金：新疆生产建设兵团第六师五家渠市科技计划项目(师市办发[2023]15号);新疆生产建设兵团第六师奇台医院能力提升项目(2331)。

摘　　要：目的观察静脉溶栓联合介入治疗对急性脑梗死患者的临床效果。方法回顾性选取2022年2月—2024年3月新疆生产建设兵团第六师奇台医院收治的70例急性脑梗死患者的临床资料,根据不同治疗方法分为研究组和对照组,各35例。对照组行静脉溶栓治疗,研究组行静脉溶栓联合介入治疗。分析两组患者的血管再通情况、神经功能、血清学指标和脑血管的血流速。结果治疗后,研究组血管再通情况优于对照组,差异有统计学意义(P<0.05)。治疗24 h和1个月后,两组患者的美国国立卫生研究院卒中量表评分(Na⁃tional Institute of Health Stroke Scale,NIHSS)均低于治疗前,且研究组治疗24 h和治疗1个月后的NIHSS评分(11.62±0.73)分、(4.61±0.24)分均低于对照组的(14.22±1.06)分、(7.38±0.52)分,差异有统计学意义(t=11.951、28.614,P均<0.05)。治疗24 h后,两组患者的血清学指标水平低于治疗前,研究组血清学指标水平低于对照组,差异有统计学意义(P均<0.05)。治疗24 h后,两组患者的大脑中动脉的收缩期最大血流速度(maximum systolic blood flow velocity,Vs)、舒张期最小血流流速(minimum diastolic blood flow velocity,Vd)和平均血流速度(mean blood flow velocity,Vm)水平均高于治疗前,且研究组Vs、Vd和Vm水平均高于对照组,差异有统计学意义(P均<0.05)。结论针对急性脑梗死患者,给予静脉溶栓联合介入治疗能有效改善神经功能,血管再通率较高,且能进一步改善患者的血清学指标和脑血管血流速。Objective To observe the clinical effect of intravenous thrombolysis combined with interventional therapy in patients with acute cerebral infarction.Methods The clinical data of 70 patients with acute cerebral infarction ad⁃mitted to Qitai Hospital of the Sixth Division of Xinjiang Production and Construction Corps from February 2022 to March 2024 were retrospectively selected.According to different treatment methods,they were divided into study group and control group,with 35 cases in each group.The control group was treated with intravenous thrombolysis,and the study group was treated with intravenous thrombolysis combined with interventional therapy.The vascular re⁃canalization,neurological function,serological indexes and cerebral blood flow velocity of the two groups were ana⁃lyzed.Results After treatment,the recanalization of blood vessels in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).After 24 hours and 1 month of treatment,the National Institute of Health Stroke Scale(NIHSS)scores of the two groups were lower than those before treatment,and the NIHSS scores of the study group at 24 hours and 1 month after treatment were(11.62±0.73)points and(4.61±0.24)points,which were lower than the control group's(14.22±1.06)points and(7.38±0.52)points,the differences were sta⁃tistically significant(t=11.951,28.614,both P<0.05).After 24 hours of treatment,the levels of serological indexes in the two groups were lower than those before treatment,and the levels of serological indexes in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).After 24 h of treatment,the levels of maximum systolic blood flow velocity(Vs),minimum diastolic blood flow velocity(Vd)and mean blood flow velocity(Vm)in the middle cerebral artery of the two groups were higher than those before treatment,and the lev⁃els of Vs,Vd and Vm in the study group were higher than those in the control group,the dif

关 键 词：急性脑梗死 静脉溶栓 介入治疗 神经功能 再通率 

分 类 号：R743.3[医药卫生—神经病学与精神病学]