小剂量喹硫平治疗老年器质性失眠及非器质性失眠的对照研究  

Comparative Study of Low-dose Quetiapine in the Treatment of Organic Insomnia and Non-organic Insomnia in the Elderly

作　　者：廖节凤 王帅 徐小红 吴丹 LIAO Jiefeng;WANG Shuai;XU Xiaohong;WU Dan(Department of Psychiatry,Tongling Third People's Hospital,Tongling,Anhui,244000,China)

机构地区：[1]铜陵市第三人民医院精神科,安徽铜陵244000

出　　处：《中外医疗》2024年第25期107-110,127,共5页China & Foreign Medical Treatment

基　　金：铜陵市科研基金项目[卫科研(2021)21号]。

摘　　要：目的探究喹硫平对老年器质性失眠及非器质性失眠患者的疗效。方法回顾性选取2021年12月—2024年6月铜陵市第三人民医院收治的39例器质性失眠患者(研究组)和38例非器质性失眠患者(对照组)的临床资料,两组均予喹硫平100 mg睡前口服治疗8周,比较两组治疗前和治疗4周和8周后的临床疗效、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)、阿森斯失眠量表(Athens Insomnia Scale,AIS)和爱泼沃斯嗜睡量表(Epworth Sleepiness Scale,ESS)、副反应量表(Treatment Emergent Symptom Scale,TESS)评分以及不良反应发生情况。结果两组治疗4周后和治疗8周后的治疗总有效率比较,差异无统计学意义(P均>0.05)。与治疗前相比,治疗4周和8周后,两组PSQI评分、AIS评分均下降,差异有统计学意义(P均<0.05);治疗后,两组PSQI、AIS评分比较,差异无统计学意义(P均>0.05)。与治疗前比较,两组治疗4周后和治疗8周后的ESS评分均降低,且研究组低于对照组,差异有统计学意义(P均<0.05)。治疗4周后,研究组TESS评分低于对照组,差异有统计学意义(P<0.05)。治疗8周后,两组TESS评分比较,差异无统计学意义(P>0.05)。研究组不良反应发生率为15.38%(6/39),低于对照组的42.11%(16/38),差异有统计学意义(χ^(2)=6.734,P<0.05)。结论喹硫平对器质性失眠及非器质性失眠症患者均有效,但维持治疗对器质性失眠患者更有效。Objective To explore the effect of quetiapine on elderly patients with organic insomnia and non-organic insomnia.Methods The clinical data of 39 patients with organic insomnia(study group)and 38 patients with non-organic insomnia(control group)admitted to Tongling Third People's Hospital from December 2021 to June 2024 were retrospectively selected.Both groups were treated with quetiapine 100 mg orally before bedtime for 8 weeks.The clini⁃cal efficacy,scores of Pittsburgh Sleep Quality Index(PSQI),Athens Insomnia Scale(AIS),Epworth Sleepiness Scale(ESS)and Treatment Emergent Symptom Scale(TESS)before treatment and after 4 weeks and 8 weeks of treatment and adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate of treatment between the two groups after 4 weeks and 8 weeks of treatment(all P>0.05).Compared with before treatment,after 4 weeks and 8 weeks of treatment,the PSQI score and AIS score of the two groups decreased,and the differences were statistically significant(all P<0.05).After treatment,there was no significant difference in PSQI and AIS scores between the two groups(all P>0.05).Compared with before treatment,the ESS scores of the two groups decreased after 4 weeks and 8 weeks of treatment,and the study group was lower than the control group,the differences were statistically significant(all P<0.05).After 4 weeks of treatment,the TESS score of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,there was no significant difference in TESS score between the two groups(P>0.05).The incidence of ad⁃verse reactions in the study group was 15.38%(6/39),which was lower than 42.11%(16/38)in the control group,and the difference was statistically significant(χ^(2)=6.734,P<0.05).Conclusion Quintiapine is effective in patients with or⁃ganic insomnia and non-organic insomnia,but maintenance treatment is more effective in patients with organic insom⁃n

关 键 词：喹硫平 器质性失眠 非器质性失眠 

分 类 号：R749[医药卫生—神经病学与精神病学]