连翘解毒汤加味治疗慢性牙周炎胃火炽盛证临床研究  

Clinical Study on Modified Lianqiao Jiedu Decoction for Chronic Periodontitis with Intense Stomach Fire Syndrome

作　　者：周波 蒋宁峙 李金华[2] ZHOU Bo;JIANG Ningzhi;LI Jinhua(Dongxin Street Community Health Service Center,Gongshu District of Hangzhou,Hangzhou Zhejiang 310011,China;Hangzhou First People's Hospital,Hangzhou Zhejiang 310003,China)

机构地区：[1]杭州市拱墅区东新街道社区卫生服务中心,浙江杭州310011 [2]杭州市第一人民医院,浙江杭州310003

出　　处：《新中医》2024年第21期33-37,共5页New Chinese Medicine

摘　　要：目的:观察连翘解毒汤加味治疗慢性牙周炎胃火炽盛证临床疗效。方法:观察病例为2021年2月—2023年6月收治的慢性牙周炎病例,共92例。随机分为对照组与治疗组各46例。对照组接受牙周炎常规治疗措施;治疗组在对照组治疗方案的基础上予连翘解毒汤加味治疗。2组持续治疗4周。比较2组疼痛视觉模拟评分法(VAS)评分、牙周炎相关指标、牙龈微循环相关指标、龈沟液白细胞介素-6(IL-6)和前列腺素E_(2)(PGE_(2))水平,以及临床疗效。结果:治疗2周后、治疗4周后,2组疼痛VAS评分均较治疗前降低,治疗组疼痛VAS评分均较对照组同期评分低,差异均有统计学意义(P<0.05)。治疗4周后,2组牙周炎相关指标菌斑指数、牙龈指数、探针深度、龈沟出血指数均较治疗前降低,治疗组牙周炎相关指标上述各项指数均低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,2组牙龈血流量均较治疗前增多,血流速度较治疗前加快,治疗组牙龈血流量多于对照组,血流速度快于对照组,差异均有统计学意义(P<0.05)。治疗4周后,2组龈沟液IL-6和PGE_(2)水平均较治疗前降低,治疗组龈沟液IL-6和PGE_(2)水平低于对照组,差异均有统计学意义(P<0.05)。临床疗效总有效率治疗组93.48%,对照组76.09%,差异均有统计学意义(P<0.05)。结论:连翘解毒汤加味治疗慢性牙周炎胃火炽盛证,可抑制炎症反应,有效改善牙周炎相关指标,改善牙龈微循环,减轻疼痛,提高临床疗效。Objective:To observe the clinical effect of modified Lianqiao Jiedu Decoction in treating chronic periodontitis with intense stomach fire syndrome.Methods:The observed cases were 92 cases of chronic periodontitis treated from February 2021 to June 2023.They were randomly divided into the control group and the treatment group,with 46 cases in each group.The control group received routine treatment measures for periodontitis;the treatment group received modified Lianqiao Jiedu Decoction based on the treatment of the control group.Two groups received continuous treatment for four weeks.The scores of the Visual Analogue Scale(VAS)for pain,periodontitis-related indicators,gingival microcirculation-related indicators,the levels of interleukin-6(IL-6)and prostaglandin E_(2)(PGE_(2))in gingival crevicular fluid,and clinical effects were compared between the two groups.Results:After two weeks and four weeks of treatment,the scores of VAS for pain in both groups were decreased compared to those before treatment,and the scores of VAS for pain in the treatment group were lower than those in the control group during the same period,with differences being significant(P<0.05).After four weeks of treatment,the plaque indexes,gingival indexes,probe depth,and gingival bleeding indexes related to periodontitis in both groups were significantly reduced compared to those before treatment,and the above periodontitisrelated indicators in the treatment group were lower than those in the control group,with differences being significant(P<0.05).After four weeks of treatment,both groups showed a significant increase in gingival blood flow and blood flow velocity when compared with those before treatment,and the gingival blood flow and blood flow velocity in the treatment group were higher than those in the control group,with differences being significant(P<0.05).After four weeks of treatment,the levels of IL-6 and PGE_(2)in the gingival crevicular fluid in the two groups were significantly reduced when compared with those before treatment,

关 键 词：牙周炎 连翘解毒汤 牙龈微循环 白细胞介素-6 前列腺素E_(2) 疼痛 

分 类 号：R781.42[医药卫生—口腔医学]