静电纺丝技术在神经组织工程中的应用进展  

The Application Progress of Electrospinning Technology in Nerve Tissue Engineering

作　　者：宋文杰 杨琪苑 阚诗琦 陶奕杉(综述) 陈良娇(审校)[1] SONG Wenjie;YANG Qiyuan;KAN Shiqi;TAO Yishan;CHEN Liangjiao(Department of Orthodontics,Affiliated Stomatology Hospital of Guangzhou Medical University,Guangdong Engineering Research Center of Oral Restoration and Reconstruction,Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine,Guangzhou 510182,Guangdong,China)

机构地区：[1]广州医科大学附属口腔医院正畸科·广东省口腔组织修复与重建工程技术研究中心·广州市口腔再生医学基础与应用研究重点实验室,广东广州510182

出　　处：《中国美容医学》2024年第11期185-188,共4页Chinese Journal of Aesthetic Medicine

基　　金：广州医科大学大学生实验室开放项目[编号:广医大发[2020]50号:28]。

摘　　要：壳聚糖、丝素蛋白、聚己内酯和聚乳酸-羟基乙酸共聚物等生物材料可通过静电纺丝技术制备成神经组织工程支架。此类支架具有生物相容性较好、可降解、比表面积大和孔隙率高等优良特点,可通过仿生细胞外基质结构、负载神经营养药物和结合电刺激等促进受损神经再生,因此在神经组织工程中备受关注。本文对常用于神经组织工程的静电纺丝材料以及静电纺丝技术在神经组织工程中的应用进行综述。Biomaterials such as chitosan,silk fibroin,polycaprolactone and polylactic-co-glycolic acid copolymer can be prepared into nerve tissue engineering scaffolds by electrospinning.Such scaffolds have good biocompatibility,degradability,large specific surface area and high porosity.They can promote the regeneration of damaged nerves by biomimetic extracellular matrix structure,loading neurotrophic drugs and combining electrical stimulation.Therefore,they have attracted much attention in nerve tissue engineering.This article reviews the electrospinning materials commonly used in nerve tissue engineering and the application of electrospinning technology in nerve tissue engineering.

关 键 词：静电纺丝 细胞外基质 神经组织工程 再生 支架 

分 类 号：R783.1[医药卫生—口腔医学]