酒精性及急、慢性胰腺炎与胰腺癌的相关性研究:基于双样本孟德尔随机化  

Association between acute,chronic,alcoholic pancreatitis and pancreatic cancer:based on two-sample Mendelian randomization

作　　者：肖玉婷 戴婷 刘丹[1] 张红辉[1] Xiao Yuting;Dai Ting;Liu Dan;Zhang Honghui(Department of Hepatobiliary Surgery,Hunan Provincial People′s Hospital,Changsha 410005,China)

机构地区：[1]湖南省人民医院肝胆外科,长沙410005

出　　处：《中华肝胆外科杂志》2024年第10期771-775,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：2022年湖南省卫生健康人才青年骨干人才(20230508-1020)。

摘　　要：目的明确急、慢性胰腺炎与酒精性胰腺炎是否在基因层面与胰腺癌的发病相关。方法使用欧洲血统的全基因组关联研究(GWAS)的汇总数据,从GWAS网站获得英国人群胰腺癌相关数据,从芬兰数据库R10版本中分别获得芬兰人群急、慢性胰腺炎及急慢性酒精性胰腺炎数据。通过以逆方差加权法为主的5种孟德尔分析方法,分别对急、慢性胰腺炎及急、慢性酒精性胰腺炎与胰腺癌的相关性进行双样本孟德尔随机化分析。对符合假设的分析结果分别进行Q异质性检验、多效性检验及反向检验以确保结果稳健。结果慢性胰腺炎与胰腺癌发病呈现显著的正向相关性(OR=1.332,95%CI:1.044~1.698,P=0.021),Q异质性检验、多效性检验及反向孟德尔随机化结果提示结果稳健,均P>0.05。而急性胰腺炎(P=0.953)、急性酒精性胰腺炎(P=0.862)与慢性酒精性胰腺炎(P=0.682)则未发现与胰腺癌发病的显著相关关系。结论本研究进一步从基因层面明确了慢性胰腺炎与胰腺癌发生存在较强的相关关系。ObjectiveTo explore whether acute pancreatitis,chronic pancreatitis and alcoholic pancreatitis are related to the incidence of pancreatic cancer in Mendelian randomization study.MethodsUsing data from a genome-wide association study(GWAS)of European ancestry,the pancreatic cancer data in the UK population is obtained from the GWAS.Acute,chronic,and alcoholic pancreatitis data in the Finnish population is obtained from the Finnish database version R10.The correlation between acute,chro-nic pancreatitis,alcoholic pancreatitis and pancreatic cancer was analyzed by two-sample Mendelian randomization through five Mendelian analysis methods mainly based on inverse variance weighting.Q heterogeneity test,pleiotropy test and reverse test were carried out to ensure the robustness of the results.ResultsChronic pancreatitis was positively associated with pancreatic cancer(OR=1.332,95%CI:1.044-1.698,P=0.021).The results of Q heterogeneity test,pleiotropy test and reverse Mendelian randomization showed that the conclusions were reliability,all P>0.05.While acute pancreatitis(P=0.953),acute alcoholic pancreatitis(P=0.862)and chronic alcoholic pancreatitis(P=0.682)were not significantly associated with pancreatic cancer.ConclusionThis study further confirmed the strong correlation between chronic pancreatitis and pancreatic cancer at the genetic level.

关 键 词：胰腺炎 胰腺癌 孟德尔随机化 

分 类 号：R735.9[医药卫生—肿瘤]