脑出血后氧化应激的研究进展  

Recent advance in oxidative stress after intracranial hemorrhage

作　　者：杨小琦 丁建林 王中 李奕江 王俊驰 邓学海 王梓旭 陈钇潜 赵龙[1] Yang Xiaoqi;Ding Jianlin;Wang Zhong;Li Yijiang;Wang Junchi;Deng Xuehai;Wang Zixu;Chen Yiqian;Zhao Long(Department of Neurosurgery,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Department of Stomatology,North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院临床医学院附属医院神经外科,南充637000 [2]川北医学院口腔医学院,南充637000

出　　处：《中华神经医学杂志》2024年第10期1043-1049,共7页Chinese Journal of Neuromedicine

基　　金：四川省大学生创新创业训练计划项目(S202310634084、S202310634101);川北医学院附属医院高层次人才项目(2023-2GC005)。

摘　　要：脑出血(ICH)是一种严重的出血性脑血管疾病,具有较高的发病率和死亡率。氧化应激在ICH后的病理生理过程中起着重要作用,也是临床治疗潜在的有效目标。本文就ICH后氧化应激的发生机制、氧化应激的损伤机制、氧化应激的检测与治疗等方面研究进展进行综述,以期为ICH相关的基础研究、临床实践提供参考。Intracerebral hemorrhage(ICH)is a hemorrhagic cerebrovascular disease with high incidence and mortality.Oxidative stress response plays an important role in the pathological and physiological processes of ICH,and is also a potential effective target for clinical treatment.In this paper,the pathogenesis of oxidative stress after ICH,mechanism of nerve and vascular injury in oxidative stress,and detection and treatment of oxidative stress are reviewed in order to provide references for basic research and clinical practice in ICH.

关 键 词：脑出血 氧化应激 自由基 

分 类 号：R743.34[医药卫生—神经病学与精神病学]