垂体腺瘤异质性表现及其临床意义的研究进展  

Recent advance in heterogeneous manifestations of pituitary adenomas and their clinical significance

作　　者：林绍涌 陈宇晖 李军 王守森 Lin Shaoyong;Chen Yuhui;Li Jun;Wang Shousen(Department of Neurosurgery,Fuzong Clinical Medical College of Fujian Medical University(900 Hospital),Fuzhou,350025,China)

机构地区：[1]福建医科大学福总临床医学院(第九〇〇医院)神经外科,福州350025

出　　处：《中华神经医学杂志》2024年第10期1064-1068,共5页Chinese Journal of Neuromedicine

摘　　要：肿瘤的异质性是恶性肿瘤的特征之一,是指肿瘤在生长过程中,经过多次分裂增殖,其子细胞呈现出分子生物学或基因方面的改变,从而使肿瘤的生长速度、侵袭能力、对药物的敏感性、预后等方面发生变化。垂体腺瘤(PAs)通常被认为是良性肿瘤,异质性表现往往不太明显,而识别可靠的异质性标志物在临床诊疗中起关键作用。在临床实践中,PAs的异质性包括其影像学表现、组织病理表现及分子生物学表现等方面。本文综述PAs异质性方面的研究进展,以期为临床研究和实践提供参考。Tumor heterogeneity is one of the characteristics of malignant tumors,which refers to the molecular biology or genetic changes in the daughter cells of tumors after multiple division and proliferation during the growth process,resulting in changes in tumor growth rate,invasion ability,drug sensitivity,and prognoses.Pituitary adenomas(PAs)are generally considered as benign tumors without obvious heterogeneity,but the identification of reliable heterogeneity markers still plays a key role in clinical diagnosis and treatment.In clinical practice,the heterogeneity of parenchymal PAs includes differences in imaging findings,histopathological findings,and molecular information.This article reviews the research results in PAs heterogeneity so as to provide better enlightenment for clinical research and practice.

关 键 词：垂体腺瘤 异质性 影像学 病理学 分子生物学 

分 类 号：R736.4[医药卫生—肿瘤]