基于星形胶质细胞能量代谢探究癫痫的发病与治疗  

Exploration of pathogenesis and treatment of epilepsy based on astrocyte energy metabolism

作　　者：张紫昊 李一鸣 王伟涛 张道培 张怀亮 Zhang Zihao;Li Yiming;Wang Weitao;Zhang Daopei;Zhang Huailiang(Department of Encephalopathy,First Affiliated Hospital of He'nan University of Traditional Chinese Medicine/Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine,Zhengzhou 450000,China;Department of Breast Surgery,Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China;He'nan Vertigo Disease Diagnostic and Treatment Center,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院脑病科/中西医防治重大疾病河南省协同创新中心,郑州450000 [2]南京中医药大学附属医院乳腺外科,南京210023 [3]河南省眩晕病诊疗中心,郑州450000

出　　处：《中华神经医学杂志》2024年第10期1069-1073,共5页Chinese Journal of Neuromedicine

基　　金：张怀亮全国名老中医药专家传承工作室建设项目(国中医药人教函[2018]134号);河南省中医药科学研究专项(2018JDZX012);吴阶平医学基金会基金(320.6750.18326)。

摘　　要：星形胶质细胞在维持中枢神经系统稳态和功能方面发挥着关键作用,其自身或毒性状态下介导的脂质异常积累、铁死亡、乳酸升高、高DNA甲基化等与癫痫发作尤为密切。近年来,从星形胶质细胞能量代谢角度治疗癫痫成为研究热点。代谢疗法,例如生酮饮食,可通过维持星形胶质细胞稳态等多种机制抑制癫痫发作。本文对星形胶质细胞能量代谢与癫痫发病机制的可能联系及相关代谢疗法进行综述,以期为耐药性癫痫患者的临床治疗提供新思路。Astrocytes play a key role in maintaining the homeostasis and function of the central nervous system.Abnormal lipid accumulation,ferroptosis,elevated lactic acid,and high DNA methylation mediated by astrocytes in their own or toxic states are particularly closely related to seizures.In recent years,epilepsy treatment from astrocyte energy metabolism perspective has become a research hotspot.Metabolic therapy,such as ketogenic diet,can inhibit seizures via a variety of mechanisms as astrocyte homeostasis maintenance.This paper reviews the relationship between astrocyte energy metabolism and epilepsy pathogenesis and its related metabolic therapy,in order to provide new ideas for clinical treatment of drug-resistant epilepsy.

关 键 词：癫痫 星形胶质细胞 脂质积累 乳酸 腺苷 酮体 

分 类 号：R742.1[医药卫生—神经病学与精神病学]