神经炎症在围绝经期抑郁症中的作用机制  

The mechanism of neuroinflammation in perimenopausal depression

作　　者：黄肖蕾 孙晓换 胡艺方 尹丽华 胡晓霞 陈迎圆 张宜生[1] HUANG Xiaolei;SUN Xiaohuan;HU Yifang;YIN Lihua;HU Xiaoxia;CHEN Yingyuan;ZHANG Yisheng(The Affiliated Lihuili Hospital of Ningbo University,Ningbo 315046,China)

机构地区：[1]宁波大学附属李惠利医院,宁波315046

出　　处：《生命的化学》2024年第10期1857-1863,共7页Chemistry of Life

基　　金：宁波市科技计划项目(2019C50091);宁波市科技计划项目(2023Z185);浙江省医药卫生科技计划项目(2022KY297);宁波市医学科技计划项目(2021Y02)。

摘　　要：女性在围绝经期伴随着雌激素水平的下降,可能发生如睡眠障碍、快感缺失、记忆力和注意力减弱等抑郁症状。在抑郁症状的发病机制中,神经炎症可能发挥着重要作用。本文从下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴失调以及5-羟色胺和突触可塑性的改变等角度分析了神经炎症导致围绝经期抑郁发生的可能机制,并提示抗炎治疗在治疗围绝经期抑郁中的潜在作用。With the decrease of estrogen levels,women may experience depression symptoms such as sleep disorders,loss of pleasure,decreased memory and attention during the perimenopausal period.Neuroinflammation may play an important role in the pathogenesis of depressive symptoms.This review analyzes the possible mechanisms of neuroinflammation caused perimenopausal depression from the perspectives of dysfunction of hypothalamic-pituitary-adrenal(HPA)axis and changes in serotonin and synaptic plasticity,and reminds the potential role of anti-inflammatory therapy in the treatment of perimenopausal depression.

关 键 词：神经炎症 围绝经期抑郁症 雌激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]