肠道微生物群与帕金森病:探索新的治疗路径  

Gut microbiota and Parkinson's disease:exploring new therapeutic pathways

作　　者：李建琳 李在普 吴林[3] LI Jianlin;LI Zaipu;WU Lin(School of Clinical Medicine,Shandong Second Medical University,Weifang 261000,China;School of Clinical Medicine,Jining Medical College,Jining 272000,China;Neurological Department of People's Hospital of Rizhao,Rizhao 276800,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊261000 [2]济宁医学院临床医学院,济宁272000 [3]日照市人民医院神经内科,日照276800

出　　处：《生命的化学》2024年第10期1872-1877,共6页Chemistry of Life

基　　金：山东省医药卫生科技发展计划项目(202003070384)。

摘　　要：帕金森病(Parkinson's disease,PD)是一种快速增长的神经退行性疾病,其病理特征主要为黑质部的多巴胺能神经元减少和α-突触核蛋白聚集。肠道微生物群通过微生物群-肠-脑轴影响PD的发展,具体表现在免疫、内分泌和神经系统的调节作用。本文分析了肠道微生物群对大脑功能的可能影响机制,并探讨了通过调整饮食模式、粪便微生物群移植、益生菌等方法调节肠道微生物群,从而为PD的治疗提供新的策略。此外,本文还回顾了PD治疗中肠道微生物群的作用,并提出了未来研究方向,以期为PD的治疗提供更多的可能性和新的治疗视角。Parkinson's disease(PD)is a rapidly growing neurodegenerative disorder,primarily characterized by the reduction of dopaminergic neurons and the accumulation of alpha-synuclein in the substantia nigra.Recent studies have shown that the gut microbiota influences the development of PD through the microbiotagut-brain axis,particularly in the regulation of the immune,endocrine and nervous systems.This work comprehensively analyzes the potential mechanisms by which the gut microbiota can affect brain function and discusses new strategies for the treatment of PD through dietary adjustments,fecal microbiota transplantation,and probiotics.Additionally,this work reviews the role of the gut microbiota in the treatment of PD and proposes future research directions to provide more possibilities and new perspectives for the treatment of the disease.

关 键 词：帕金森病 肠道微生物群 微生物群-肠-脑轴 治疗策略 

分 类 号：R742.5[医药卫生—神经病学与精神病学]