丛状神经纤维瘤的复发影响因素  

Factors affecting recurrence of plexiform neurofibromas

作　　者：谭好 朱子骋 苏佳琦 黄健峰 曾丹奕 王智超 TAN Hao;ZHU Zicheng;SU Jiaqi;HUANG Jianfeng;ZENG Danyi;WANG Zhichao(Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China.)

机构地区：[1]上海交通大学医学院,上海市200025 [2]上海交通大学医学院附属第九人民医院整复外科,上海市200011

出　　处：《组织工程与重建外科》2024年第5期579-583,共5页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(82472579,82102344,82172228,82202470);上海市整形外科重点研究中心(2023ZZ02023);上海市科学技术委员会临床医学研究中心项目(22MC1940300);上海交通大学医学院附属第九人民医院生物样本库项目(YBKA202204);上海交通大学医学院创新训练项目(1723Y035)。

摘　　要：丛状神经纤维瘤(Plexiform neurofibromas,pNF)是神经系统常染色体显性遗传疾病,手术治疗为其主要治疗方法,然而pNF难以彻底切除,常出现术后复发。本文主要通过广泛检索和查阅基于队列研究的相关文献,来探讨pNF患者术后复发的影响因素。pNF的复发主要与原发肿瘤的生长部位、手术切除程度、患者年龄相关,其他因素如肿瘤生长模式、侵犯深度、神经起源、术前肿瘤大小、肿瘤疼痛程度等是pNF复发的可能影响因素。目前,pNF仍缺少基于多种因素的术前评估标准,更多需要依赖临床经验进行手术判断。既往的研究中存在着样本量小、患者分类不精细、研究因素较单一、未进行综合量化处理等问题,有待新的临床队列研究提供进一步的证据支持与预后评估标准。Plexiform neurofibromas(pNF)is an autosomal dominant condition of the nervous system and surgical treatment is the main treatment for pNF.However,it is difficult to remove completely,and postoperative recurrence is common.Based on extensive investigation of domestic and foreign cohort research,the existing factors affecting recurrence of pNF were summarized and analyzed.The recurrence of pNF is mainly related to the location of the primary tumor,the extent of surgical resection,and the age of the patients.Other factors such as tumor growth pattern,depth of invasion,nerve origin,preoperative tumor size,and degree of tumor pain are possible affecting factors for recurrence.At present,there is still a lack of preoperative comprehensive evaluation criteria based on multiple factors,and it is more necessary to rely on the experience of clinicians for surgical judgment.There are some problems in previous studies,such as small sample size,imprecise classification of patients,the factors studied were relatively single,and lack of comprehensive quantitative processing.New clinical cohort studies are needed to provide further evidence support and prognostic evaluation criteria.

关 键 词：丛状神经纤维瘤 复发 队列研究 

分 类 号：R730.264[医药卫生—肿瘤]