中国移植肾系统性疾病肾损害复发临床诊疗指南  

Guidelines for clinical diagnosis and treatment of recurrence of systemic disease-related renal damage in transplant kidney in China

作　　者：中华医学会器官移植学分会 于峰 赵洪雯 秦燕[4] 廖贵益 文吉秋 Branch of Organ Transplantation of Chinese Medical Association;Wen Jiqiu;无(不详;Peking University International Hospital,Beijing 102206,China)

机构地区：[1]不详 [2]北京大学国际医院,北京102206 [3]陆军军医大学西南医院 [4]上海交通大学医学院附属上海市第一人民医院 [5]安徽医科大学附属第一医院 [6]广西医科大学第二附属医院

出　　处：《器官移植》2024年第6期846-862,共17页Organ Transplantation

基　　金：上海市卫健委面上课题(201940470)。

摘　　要：原发病复发是影响移植肾近期和远期存活的重要原因,越来越受到重视。系统性疾病肾损害在肾脏移植术后均有可能复发,并不同程度损伤移植肾。随着对系统性疾病肾损害发病机制的深入认识,移植肾系统性疾病肾损害复发的诊治水平也在逐渐提升。中华医学会器官移植学分会组织器官移植专家,充分阅读、分析和总结目前国际和国内的文献,在《慢性移植肾功能不全诊疗技术规范(2019版)》的基础上,对系统性疾病肾损害复发的危险因素、预防措施、治疗措施及预后等内容,依据推荐评估、发展和评价分级方法对证据质量和建议强度进行客观评估,制定《中国移植肾系统性疾病肾损害复发临床诊疗指南》,在本指南中对相应临床问题提出推荐意见,以更好地保障和促进移植肾脏和受者的长期存活。The recurrence of primary disease is an important cause affecting the short-term and long-term survivalof transplant kidney,which receives increasing attention.Systemic disease-related renal damage may recur after kidneytransplantation and cause varying degrees of damage to the transplant kidney.With an in-depth understanding of thepathogenesis of systemic disease-related renal damage,the level of diagnosis and treatment of recurrence of systemicdisease-related renal damage in transplant kidney is gradually improving.Branch of Organ Transplantation of ChineseMedical Association organized organ transplantation experts to fully read,analyze,and summarize the currentinternational and domestic literature.On the basis of"Technical Specification for Diagnosis and Treatment of ChronicRenal Allograft Dysfunction(2019 edition)",the risk factors,preventive measures,treatment measures,and prognosis ofthe recurrence of systemic disease-related renal damage were evaluated based on the Grading of RecommendationsAssessment,Development and Evaluation for evidence quality and recommendation strength.The"Guidelines for ClinicalDiagnosis and Treatment of Recurrence of Systemic Disease-Related Renal Damage in Transplant Kidney in China"wereformulated,which provide recommendations for corresponding clinical issues to better ensure and promote the long-termsurvival of transplant kidneys and recipients.

关 键 词：肾脏移植 系统性疾病肾损害 复发 狼疮性肾炎 抗中性粒细胞胞质抗体相关性血管炎 抗肾小球基底膜肾炎 免疫球蛋白轻链淀粉样变性 原发性高草酸尿症 

分 类 号：R617[医药卫生—外科学] R692[医药卫生—临床医学]