迷迭香精油与β-环糊精包合物缓释性能研究  

Study on the Sustained-Release Performance of Rosemary Essential Oil andβ-Cyclodextrin Inclusion Complex

作　　者：袁思珩 姜雪峰 YUAN Si-heng;JIANG Xue-feng(Shanghai Key Laboratory of Green Chemistry and Chemical Progress,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062,China)

机构地区：[1]华东师范大学化学与分子工程学院上海市绿色化学与化工过程绿色化重点实验室,上海200062

出　　处：《化学试剂》2024年第11期36-41,共6页Chemical Reagents

基　　金：2023年度国家大学生创新创业训练计划项目(202310269046G)。

摘　　要：迷迭香精油有提神、抗氧化、抗炎、抗菌的功效,但其强挥发性限制了其在化妆品、医药、食品等领域的长效使用。将迷迭香精油与β-环糊精包合可以显著增强稳定性,并达到缓释效果,延长迷迭香精油的保留时间。采用冷冻干燥法制备了β-环糊精包合物,并通过单因素试验发现:m(β-环糊精)∶m(迷迭香精油)=7∶1,温度为50℃,时间为2.5 h时,所得缓释物的包合率最高。核磁共振氢谱的特征峰迁移,进一步证明了包合物的生成;扫描电镜观察,阐释了包合物的微观形貌变化;薄层色谱检测,验证了迷迭香精油的化学组分在包合过程中并未改变。挥发量/时间曲线观察到储存35 d之后,纯精油挥发量为79%,而β-环糊精包合物挥发量为36%,明确阐释了β-环糊精包合物的缓释性能。Rosemary essential oil is known for its stimulating,antioxidant,anti-inflammatory,and antibacterial effects,but its strong volatility limits its long-term use in cosmetics,pharmaceuticals,and food industries.Complexing rosemary essential oil withβ-cyclodextrin significantly enhances its stability and achieves a sustained-release effect,thereby prolonging the retention time of rosemary essential oil.This study used the freeze-drying method to prepare theβ-cyclodextrin inclusion complex and found through a single-factor experiment that the optimal mass ratio ofβ-cyclodextrin to rosemary essential oil is 7∶1,at a temperature of 50℃and a duration of 2.5 hours,resulting in the highest inclusion rate.Further evidence of complex formation is provided by shifts in characteristic peaks in the proton nuclear magnetic resonance spectra.Scanning electron microscopy observations elucidate the microscopic morphology changes of the inclusion complex,while thin-layer chromatography confirms that the chemical composition of rosemary essential oil remained unchanged during the complexation process.Volatility/time curves observed after 35 days of storage demonstrated that while the pure essential oil had a volatility of 79%,theβ-cyclodextrin inclusion complex showed significantly reduced volatility at 36%,illustrating its effective sustained-release properties.

关 键 词：迷迭香精油 Β-环糊精 冷冻干燥法 Β-环糊精包合物 缓释 

分 类 号：TQ655[化学工程—精细化工]