基于EB病毒特异性标志物的鼻咽癌早期诊断和个体化综合治疗  

Early diagnosis and personalized comprehensive treatment of nasopharyngeal carcinoma based on Epstein-Barr virus-specific markers

作　　者：陈洁 梁树铭 刘丽婷 麦海强[1,2] CHEN Jie;LIANG Shuming;LIU Liting;MAI Haiqiang(State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou 510000,China;Department of Nasopharyngeal Carcinoma,Sun Yat-sen University Cancer Center,Guangzhou 510000,China;Sun Yat-sen University School of Medicine,Guangzhou 510000,China)

机构地区：[1]华南恶性肿瘤防治全国重点实验室,肿瘤医学省部共建协同创新中心,广东省鼻咽癌诊治研究重点实验室,广东省恶性肿瘤临床医学研究中心,中山大学肿瘤防治中心,广州510000 [2]中山大学肿瘤防治中心鼻咽癌科,广州510000 [3]中山大学中山医学院,广州510000

出　　处：《广西医科大学学报》2024年第9期1289-1295,共7页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.82173287,No.82372980)。

摘　　要：鼻咽癌是东亚及东南亚地区常见的恶性肿瘤之一,在我国华南地区尤为多见,爱泼斯坦—巴尔病毒(EBV)相关标志物是鼻咽癌重要的肿瘤标志物,也是目前临床应用最成熟、最广泛的早期筛查、诊断、预后判断及个体化治疗方案制定的重要参考指标。近年来,EBV相关的特异性标志物的开发和应用取得了很大进展,本文对其目前在鼻咽癌中的应用价值进行综述。Nasopharyngeal carcinoma(NPC)is one of the most common malignant tumors in East Asia and Southeast Asia,particularly prevalent in southern China.Epstein-Barr virus(EBV)-related markers are crucial tumor markers for NPC and are also important reference indicators for early screening,diagnosis,prognosis,and the formulation of personalized treatment plans with the most mature and extensive clinical application.In recent years,significant progress has been made in the development and application of EBV-specific markers.This article reviews their current application value in NPC.

关 键 词：鼻咽癌 EB病毒 筛查及早期诊断 预后 个体化治疗 

分 类 号：R739.63[医药卫生—肿瘤]