RNA甲基化在结直肠癌中的研究进展  

Advances in the study of RNA methylation in colorectal cancer

作　　者：李素贞 于漫亚 崔兴 LI Suzhen;YU Manya;CUI Xing(The First Clinical School,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学第二附属医院肿瘤科,250001

出　　处：《临床肿瘤学杂志》2024年第8期812-816,共5页Chinese Clinical Oncology

基　　金：国家自然科学基金面上资助项目(82074348);山东省中医药科技发展计划面上资助项目(M-2022158);济南市临床医学科技创新计划资助项目(202225014)

摘　　要：RNA甲基化是指多种RNA分子上的不同位置发生甲基化修饰,这一过程主要受到RNA甲基转移酶催化、甲基化结合蛋白翻译和去甲基化酶去甲基化的调节。RNA甲基化相关分子在结直肠癌中经常上调,促进肿瘤细胞增殖、进展、转移,其与化疗药物的耐药性也密切相关。结直肠癌是最常见的胃肠道恶性肿瘤之一,远处转移、化疗耐药性等是结直肠癌治疗失败的主要原因。其中,RNA甲基化在结直肠癌的诊断、治疗以及预后中起着举足轻重的作用。本文综述了不同类型的RNA甲基化在结直肠癌中的研究进展及应用于诊断、治疗和预后的前景。RNA methylation refers to the modification of various RNA molecules through the methylation process at distinct positions.This modification is primarily controlled by the enzymatic activity of RNA methyltransferases,the recognition of methylated sites by methylation⁃binding proteins,and the removal of methyl groups by demethylases.In colorectal cancer,RNA methylation⁃related molecules are frequently overexpressed,promoting tumor cell proliferation,progression,metastasis,and contributing to chemotherapy resistance.Colorectal cancer ranks among the most prevalent gastrointestinal malignancies worldwide,with distant metastasis and resistance to chemotherapy as major impediments to treatment success.RNA methylation assumes a crucial role in the diagnosis,treatment,and prognosis of colorectal cancer.This review discusses the progression in the study of RNA methylation types in colorectal cancer and explores prospect for the diagnosis,treatment,and prognosis of the disease.

关 键 词：结直肠癌 RNA甲基化 N6甲基腺苷 N7⁃甲基腺苷 5⁃甲基胞嘧啶 

分 类 号：R735.3[医药卫生—肿瘤]