Palladium/Xu-Phos Catalyzed Enantioselective Intramolecular Heck Reaction of Unactivated Alkenes  

作　　者：Lujia Zhou Longling Ma Bing Xu Zhan-Ming Zhang Junliang Zhang 

机构地区：[1]Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai 200438,China [2]Zhuhai Fudan Innovation Institute,Zhuhai,Guangdong 519000,China [3]Fudan Zhangjiang Institute,Shanghai 201203,China [4]Scholof Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,Chin

出　　处：《Chinese Journal of Chemistry》2024年第20期2466-2470,共5页中国化学（英文版）

基　　金：support of the National Key R&D Program of China(No.2021YFF0701600),NSFC(No.22031004);the Shanghai Municipal Education Commission(No.20212308);China Postdoctoral Science Foundation(No.2022M713667)and STCSM(No.23ZR1445600).

摘　　要：A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research.Its salient features include high yield,excellent chemo-and enantioselectivity,mild conditions,a broad substrate scope as well as versatile transformations of the product.

关 键 词：PALLADIUM HECK 2 3-Dihydrobenzofuran Asymmetric catalysis Quaternary stereocenter ENANTIOSELECTIVE P ligands ALKENES 

分 类 号：O643.3[理学—物理化学]