Construction of Acyclic Quaternary Carbon Stereocenters via Enantioselective Nickel Catalysis  

作　　者：Jian Song Xuening Li Jinguo Long Hua Yang Xianjie Fang 

机构地区：[1]College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan 410083,China [2]Key Laboratory of Organosilicon Chemistry and Material Technology of Zhejiang Province,College of Material,Chemistry and Chemical Engineering,Hangzhou Normal University,2318 Yuhangtang Road,Hangzhou,Zhejiang 311121,China [3]College of Chemistry and Chemical Engineering,State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha,Hunan 410082,China

出　　处：《Chinese Journal of Chemistry》2024年第20期2485-2498,共14页中国化学（英文版）

基　　金：National Natural Science Foundation of China(Nos.22278265,U22B20137);Zhejiang Provincial Natural Science Foundation of China(No.LR24B020002);the start-up funding from Hangzhou Normal University(No.4095C50222204165);support.J.S.thanks the Natural Science Foundation of Hunan Province(2024JJ6485);support.J.L.thanks the National Natural Science Foundation of China(22302063);China Postdoctoral Science Foundation(2022M721086);the Natural Science Foundation of Hunan Province(2023JJ40124)for financial support.

摘　　要：The construction of acyclic quaternary carbon stereocenters,which are ubiquitous in many bioactive compounds,pharmaceuticals and natural products,has been a long persuit in synthetic organic chemistry.Among numerous methods,enantioselective nickel-catalysis has attracted incremental attention in recent years.This review summarizes the recent development in the asymmetric strategies,research progress,mechanistic investigations for the generation of acyclic quaternary carbon stereocenters via enantioselective nickel catalysis.

关 键 词：Nickel catalysis ENANTIOSELECTIVITY ALKENES ACYCLIC Quaternary carbon stereocenters Asymmetric catalysis CROSS-COUPLING Chirality 

分 类 号：O64[理学—物理化学]