Treadmill Exercise Reshapes Cortical Astrocytic and Neuronal Activity to Improve Motor Learning Deficits Under Chronic Alcohol Exposure  

作　　者：Linglin Liu Lanzhi Luo Ji-an Wei Xintong Xu Kwok-Fai So Li Zhang 

机构地区：[1]Key Laboratory of CNS Regeneration(Ministry of Education),Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Jinan University,Guangzhou,510632,China [2]College of Life Science and Technology,Jinan University,Guangzhou,510632,China [3]State Key Laboratory of Brain and Cognitive Science,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pok Fu Lam,Hong Kong SAR,China [4]Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Sciences,Qingdao,266113,China [5]Center for Exercise and Brain Science,School of Psychology,Shanghai University of Sport,Shanghai,200438,China [6]The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,453003,China

出　　处：《Neuroscience Bulletin》2024年第9期1287-1298,共12页神经科学通报（英文版）

基　　金：STI2030-Major Projects(2022ZD0207600);National Key Research and Development Program of China(2020YFA0113600);National Natural Science Foundation of China(U22A20301,32070955);Key Research and Development Plan of Ningxia(2022BEG01004);Guangdong Basic and Applied Basic Research Foundation(2023B1515040015).

摘　　要：Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works.In this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions.Using a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex.Persistent treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol exposure.These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.

关 键 词：Alcohol abuse Motor learning Dendritic spine Reactive astrocyte 

分 类 号：R745[医药卫生—神经病学与精神病学]