Temporal trends and cohort variations of gender-specific major depressive disorders incidence in China:analysis based on the age-period-cohortinteraction model  

作　　者：Xiyuan Hu Chao Guo 

机构地区：[1]Department of Population Health Sciences,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,Wisconsin,USA [2]Institute of Population Research,Peking University,Beijing,China [3]APEC Health Science Academy(HeSAY),Peking University,Beijing,China

出　　处：《General Psychiatry》2024年第4期473-479,共7页综合精神医学（英文）

基　　金：supported by the National Natural Science Foundation of China(grant number 82103955);the Cyrus Tang Foundation(grant number 050459);the Clinical Medicine Plus X-Young Scholars Project,Peking University,the Fundamental Research Funds for the Central Universities(grant number 7100604313).

摘　　要：Background Major depressive disorders(MDDs)impose substantial burdens on individuals and society;however,further detailed analysis is still needed for its long-term trends.Aims This study aimed to analyse the gender-specific temporal trends and cohort variations of MDD incidence among Chinese residents over the past three decades.Methods Employing the age-period-cohort-interaction model and leveraging data from the Global Burden of Disease Study 2019,this research identified and analysed incidence trends of MDD among Chinese males and females aged 5-94 years from 1990 to 2019 across three dimensions,encompassing age,period and birth cohort.Results The analysis reveals age-related effects,indicating heightened MDD risk among adolescents and older adults.Specifically,individuals entering the older adulthood at the age of 65-69 significantly increased the risk of MDD by 64.9%.People aged 90-94 years witnesseda 105.4%increase in MDD risk for the overall population,with females and males in this age group experiencing a 75.1%and 103.4%increase,respectively.In terms of period effects,the risk of MDD displayed a decline from 1990 to 1994,followed by a rebound in 2008.Cohort effects demonstrated diverse generational patterns,with generationⅠand generationⅢmanifesting opposing‘age-as-level'trends.GenerationⅡand generationⅣexhibited'cumulative disadvantage'and'cumulative advantage'patterns,respectively.Age effects indicated an overall higher risk of MDD incidence in females,while cohort effects showed greater variations of MDD incidence among females.Conclusions The study underscores the substantial effects of age,period and cohort on MDD across genders in China.Priority interventions targeting vulnerable populations,including children,adolescents,older adults,females and the post-millennium birth cohort,are crucial to mitigate the impact of MDD.

关 键 词：INTERACTION ANALYSIS INCIDENCE 

分 类 号：R749.4[医药卫生—神经病学与精神病学]