非心脏非神经外科手术围手术期缺血性卒中的影响因素分析  

Analysis of influencing factors of perioperative ischemic stroke in non-cardiac and non-neurosurgical surgeries

作　　者：柏亚真 郑童童 范孟楠 尚益如 杜敢琴[3] 富奇志[3] Bai Ya-Zhen;Zheng Tong-Tong;Fan Meng-Nan;Shang Yi-Ru;Du Gan-Qin;Fu Qi-Zhi(College of Clinical Medicine,Henan University of Science and Technology,Luoyang,Henan 471003,China;Department of Medical Records Statistics,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China;Department of Neurology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003,China)

机构地区：[1]河南科技大学临床医学院,河南洛阳471003 [2]河南科技大学第一附属医院病案统计室,河南洛阳471003 [3]河南科技大学第一附属医院神经内科,河南洛阳471003

出　　处：《解放军医学杂志》2024年第10期1117-1122,共6页Medical Journal of Chinese People's Liberation Army

基　　金：河南省重大科技专项(221100210500)。

摘　　要：目的 探讨非心脏非神经外科手术围手术期缺血性卒中的发病率、危险因素及其与术前脑血管事件风险评估的相关性,以指导围手术期风险管理。方法 回顾性选取2015年1月-2022年1月在河南科技大学第一附属医院接受非心脏非神经外科手术、发生围手术期缺血性卒中、年龄≥18岁的40例患者作为卒中组;按照性别、年龄、手术日期、手术医师匹配,病例比1:4,选取160例未发生围手术期缺血性卒中的患者作为对照组。收集两组患者的临床资料及术前脑血管事件风险评估情况(包括单独或联合应用头颅CT/MRI、经颅多普勒超声、颈动脉超声、神经科会诊)进行统计分析。采用多因素logistic回归分析筛选围手术期缺血性卒中的危险因素。结果 围手术期缺血性卒中的发生率为0.042%。多因素logistic回归分析结果显示,高血压(OR=7.858,95%CI 2.175~28.388,P=0.002)、高脂血症(OR=4.457,95%CI 1.320~15.049,P=0.016)、肾功能不全(OR=8.277,95%CI 1.480~46.282,P=0.016)、术中低血压(OR=3.862,95%CI 1.211~12.317,P=0.022)是非心脏非神经外科手术围手术期缺血性卒中的独立危险因素;术前脑血管事件风险评估(OR=0.130,95%CI 0.031~0.542,P=0.005)是非心脏非神经外科手术围手术期缺血性卒中的保护因素。结论 围手术期缺血性卒中的发生率较低,但预后较差;其危险因素有高血压、高脂血症、肾功能不全和术中低血压,术前脑血管事件风险评估有利于降低其发生率。Objective To explore the incidence and risk factors of perioperative ischemic stroke in non-cardiac and non-neurosurgical surgeries and its correlation with preoperative risk assessment of cerebrovascular events,so as to guide perioperative risk management.Methods A retrospective study was conducted on 40 patients aged≥18 years who underwent non-cardiac and non-neurosurgical surgeries and experienced perioperative ischemic stroke in the First Affiliated Hospital of Henan University of Science and Technology from January 2015 to January 2022,forming the stroke group.A control group of 160 patients without perioperative ischemic stroke was selected in a 1:4 case-control ratio,matched for gender,age,date of operation,and the surgeon.Clinical data and preoperative risk assessment of cerebrovascular events(including the single or combined application of head CT/MRI,transcranial Doppler ultrasound,carotid ultrasound,and neurological consultation)of the two groups of patients were collected and statistically analyzed.Multiple logistic regression analysis was used to identify risk factors associated with perioperative ischemic stroke.Results The incidence of perioperative ischemic stroke was 0.042%.Multiple logistic analysis results showed that hypertension(OR=7.858,95%CI 2.175-28.388,P=0.002),hyperlipidemia(OR=4.457,95%CI 1.320-15.049,P=0.016),renal insufficiency(OR=8.277,95%CI 1.480-46.282,P=0.016),and intraoperative hypotension(OR=3.862,95%CI 1.211-12.317,P=0.022)were independent risk factors for perioperative ischemic stroke in non-cardiac and non-neurological surgeries;preoperative cerebrovascular risk assessment(OR=0.130,95%CI 0.031-0.542,P=0.005)was a protective factor against it.Conclusions The incidence of perioperative ischemic stroke in non-cardiac and non-neurosurgical surgery is low but has a poor prognosis.Hypertension,hyperlipidemia,renal insufficiency,and postoperative hypotension are risk factors for perioperative ischemic stroke,while preoperative cerebrovascular event risk assessment is beneficial to

关 键 词：非心脏非神经外科手术 围手术期 缺血性卒中 危险因素 风险评估 

分 类 号：R743.3[医药卫生—神经病学与精神病学]