The implication of dendritic cells in lung diseases:Immunological role of toll-like receptor 4  

作　　者：Shurui Xuan Yuan Ma Honglei Zhou Shengwei Gu Xin Yao Xiaoning Zeng 

机构地区：[1]Department of Pulmonary&Critical Care Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Department of Respiratory Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing,Jiangsu 210006,China [3]Department of General Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

出　　处：《Genes & Diseases》2024年第6期258-272,共15页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China,China (No.81970016,81870039).

摘　　要：The immune responses play a profound role in the progression of lung lesions in both infectious and non-infectious diseases.Dendritic cells,as the"frontline"immune cells responsible for antigen presentation,set up a bridge between innate and adaptive immunity in the course of these diseases.Among the receptors equipped in dendritic cells,Toll-like re-ceptors are a group of specialized receptors as one type of pattern recognition receptors,capable of sensing environmental signals including invading pathogens and self-antigens.Toll-like receptor 4,a pivotal member of the Toll-like receptor family,was formerly recognized as a receptor sensitive to the outer membrane component lipopolysaccharide derived from Gram-negative bacteria,triggering the subsequent response.Moreover,its other essential roles in immune responses have drawn significant attention in the past decade.A better under-standing of the implication of Toll-like receptor 4 in dendritic cells could contribute to the management of pulmonary diseases including pneumonia,pulmonary tuberculosis,asthma,acutelung injury,and lung cancer.

关 键 词：Dendritic cells IMMUNITY Lung diseases Pathogen recognition receptors Toll-like receptors 4 

分 类 号：R563[医药卫生—呼吸系统]