Comprehensive multi-omics profiling identifies novel molecular subtypes of pancreatic ductal adenocarcinoma  

作　　者：Xing Wang Jinshou Yang Bo Ren Gang Yang Xiaohong Liu Ruiling Xiao Jie Ren Feihan Zhou Lei You Yupei Zhao 

机构地区：[1]Department of General Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100023,China [2]Key Laboratory of Research in Pancreatic Tumor,Chinese Academy of Medical Sciences,Beijing 100023,China [3]National Science and Technology Key Infrastructure on Translational Medicine in Peking Union Medical College Hospital,Beijing 100023,China

出　　处：《Genes & Diseases》2024年第6期315-330,共16页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China (No.81972321,82273455to L.Y.);CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2021-I2M-1-002 to Y.Z.);the National High Level Hospital Clinical Research Funding (China) (No.2022-PUMCH-D-001);the National Multidisciplinary Cooperative Diagnosissand Treatment Capacity Building Project for Major Diseases (China).

摘　　要：Pancreatic cancer,a highly fatal malignancy,is predicted to rank as the second leading cause of cancer-related death in the next decade.This highlights the urgent need for new insights into personalized diagnosis and treatment.Although molecular subtypes of pancreatic cancer were well established in genomics and transcriptomics,few known molec-ular classifications are translated to guide clinical strategies and require a paradigm shift.Notably,chronically developing and continuously improving high-throughput technologies and systems serve as an important driving force to further portray the molecular landscape of pancreatic cancer in terms of epigenomics,proteomics,metabonomics,and metagenomics.Therefore,a more comprehensive understanding of molecular classifications at multiple levels using an integrated multi-omics approach holds great promise to exploit more potential ther-apeutic options.In this review,we recapitulated the molecular spectrum from different omics levels,discussed various subtypes on multi-omics means to move one step forward towards bench-to-beside translation of pancreatic cancer with clinical impact,and proposed some methodological andscientific challengesinstore.

关 键 词：Molecular characterization Molecular subtyping Multi-omics Pancreatic cancer Precision medicine 

分 类 号：R735.9[医药卫生—肿瘤]