Histone deacetylases:Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis  

作　　者：Hanyi Yang Kai Guo Peng Ding Jiayi Ning Yimeng Zhang Yuanyong Wang Zhaoyang Wang Guanglin Liu Changjian Shao Minghong Pan Zhiqiang Ma Xiaolong Yan Jing Han 

机构地区：[1]Department of Ophthalmology,Tangdu Hospital,The Air Force Military Medical University,Xi'an,Shaanxi 710038,China [2]Xi'an Medical University,Xi'an,Shaanxi 710086,China [3]Department of Thoracic Surgery,Shaanxi Provincial People's Hospital,The Third Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710068,China [4]Department of Thoracic Surgery,Tangdu Hospital,The Air Force Military Medical University,Xi'an,Shaanxi710038,China [5]Department of Medical Oncology,Senior Department of Oncology,Chinese PLA General Hospital,The FifthMedical Center,Beijing100853,China

出　　处：《Genes & Diseases》2024年第6期351-366,共16页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China (No.82103508,82203758);Natural Science Foundation of Shaanxi Province (China) (No.SZYKJCYC-2023-028);the Science and Technology Development Incubation Fund of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2021YJY-21);the Project of Tangdu Hospital,the Air Force Medical University,Shaanxi,China (No.XJSXYW202130,XJSXYW-2023015,2021LCYJ019);the Project of Air Foce Medical University,Shaanxi,China (No.2022LC2227);the Talent Support Program of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2022JY-38).

摘　　要：tHistone deacetylases(HDACs)are proteases that play a key role in chromosome structural modification and gene expression regulation,and the involvement of HDACs in can-cer,the nervous system,and the metabolic and immune system has been well reviewed.Our understanding of the function of HDACs in the vascular system has recently progressed,and a significant variety of HDAC inhibitors have been shown to be effective in the treatment of vascular diseases.However,few reviews have focused on the role of HDACs in the vascular sys-tem.In this study,the role of HDACs in the regulation of the vascular system mainly involving endothelial cells and vascular smooth muscle cells was discussed based on recent updates,and the role of HDACs in different vascular pathogenesis was summarized as well.Furthermore,the therapeutic effects and prospects of HDAC inhibitors were also addressed in this review.

关 键 词：DEACETYLATION Endothelial cells Histone deacetylase Vascular disease Vascular smooth muscle cells 

分 类 号：R543[医药卫生—心血管疾病]