DEACETYLATION

作品数：59被引量：229H指数：9
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相关作者：陶然温进坤更多>>
相关机构：清华大学扬州大学河北医科大学更多>>
相关期刊：《Chinese Journal of Chemistry》《Journal of Integrative Plant Biology》《Journal of Cancer Therapy》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金福建省自然科学基金更多>>
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FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation
《Science China(Life Sciences)》2025年第3期673-688,共16页Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man 
supported by the National Key Research and Development Program of China(2022YFA1303000,2017YFA0505602);the National Natural Science Foundation of China(81872408,81872153).
The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetyl...
关键词：glioblastoma multiforme(GBM) microtubule deacetylation invasion FSD1 HDAC6 
Histone deacetylases:Regulation of vascular homeostasis via endothelial cells and vascular smooth muscle cells and the role in vascular pathogenesis
《Genes & Diseases》2024年第6期351-366,共16页Hanyi Yang Kai Guo Peng Ding Jiayi Ning Yimeng Zhang Yuanyong Wang Zhaoyang Wang Guanglin Liu Changjian Shao Minghong Pan Zhiqiang Ma Xiaolong Yan Jing Han 
supported by the National Natural Science Foundation of China (No.82103508,82203758);Natural Science Foundation of Shaanxi Province (China) (No.SZYKJCYC-2023-028);the Science and Technology Development Incubation Fund of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2021YJY-21);the Project of Tangdu Hospital,the Air Force Medical University,Shaanxi,China (No.XJSXYW202130,XJSXYW-2023015,2021LCYJ019);the Project of Air Foce Medical University,Shaanxi,China (No.2022LC2227);the Talent Support Program of Shaanxi Provincial People's Hospital,Shaanxi,China (No.2022JY-38).
tHistone deacetylases(HDACs)are proteases that play a key role in chromosome structural modification and gene expression regulation,and the involvement of HDACs in can-cer,the nervous system,and the metabolic and immu...
关键词：DEACETYLATION Endothelial cells Histone deacetylase Vascular disease Vascular smooth muscle cells 
Functions and mechanisms of non-histone protein acetylation in plants^(∞)
《Journal of Integrative Plant Biology》2024年第10期2087-2101,共15页Xia Jin Xiaoshuang Li Jaime A.Teixeira da Silva Xuncheng Liu 
supported by grants from the National Natural Science Foundation of China (No. 32070551 and No. 32371326);the Youth Innovation Promotion Association, CAS (No. 201860);Key Research Program of Frontier Sciences, Chinese Academy of Sciences (ZDBS-LY-SM009)。
Lysine acetylation, an evolutionarily conserved post-translational protein modification, is reversibly catalyzed by lysine acetyltransferases and lysine deacetylases. Lysine acetylation, which was first discovered on ...
关键词：acetylomics lysine acetylation lysine deacetylation non-histone acetylation post-translational modification 
Editorial Expression of Concern:HDAC2 phosphorylationdependent Klf5 deacetylation and RARαacetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs
《Cell Research》2024年第4期331-331,共1页Bin Zheng Mei Han Ya-nan Shu Ying-jie Li Sui-bing Miao Xin-hua Zhang Hui-jing Shi Tian Zhang Jin-kun Wen 
The Editors would like to alert the readers that concerns have been raised regarding the gels and blots in the published figures.Specifically.
关键词：RARα raised alert 
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex被引量：3
《Cell Research》2023年第10期790-801,共12页Shuqi Dong Huadong Li Meilin Wang Nadia Rasheed Binqian Zou Xijie Gao Jiali Guan Weijie Li Jiale Zhang Chi Wang Ningkun Zhou Xue Shi Mei Li Min Zhou Junfeng Huang He Li Ying Zhang Koon Ho Wong Xiaofei Zhang William Chong Hang Chao Jun He 
funded by the National Natural Science Foundation of China(NSFC U20A2013,32241021 and 32170189);the R&D Program of Guangzhou Laboratory(SRPG22-003 to J.H.);the University of Macao Multi-Year Research Grant(MYRG2018-00221-FHS);the Science and Technology Development Fund,Macao SAR(FDCT file numbers 0009/2018/A1 and 0032/2021/A1);supported by the Guangzhou Basic and Applied Basic Research Foundation(202102080156);supported by the grant from the Guangdong Pearl River Talents Program(2019QN01Y051).
In Saccharomyces cerevisiae,cryptic transcription at the coding region is prevented by the activity of Sin3 histone deacetylase(HDAC)complex Rpd3S,which is carried by the transcribing RNA polymerase Ⅱ(RNAPⅡ)to deace...
关键词：NUCLEOSOME LINKER DNA 
PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation被引量：1
《Acta Biochimica et Biophysica Sinica》2023年第9期1370-1379,共10页Gongyu Fu Shi-Ting Li Zetan Jiang Qiankun Mao Nanchi Xiong Xiang Li Yijie Hao Huafeng Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.81930083,82192893,82103363,and 81821001);the Chinese Academy of Sciences(No.XDB39000000);the National Key R&D Program of China(No.2022YFA1304504);the Institute of Health and Medicine,Hefei Comprehensive National Science Center(No.DJK-LX-2022001);the Fundamental Research Funds for the Central Universities(No.YD2070002008);the China Postdoctoral Science Foundation(No.2021M700898).
Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and development.Protein lysine acetylation,which affects a variety of biological functions of proteins,plays an importan...
关键词：metabolic reprograming PGAM5 protein acetylation SIRT2 ME1 liver cancer 
OsWR2 recruits HDA704 to regulate the deacetylation of H4K8ac in the promoter of OsABI5 in response to drought stress被引量：4
《Journal of Integrative Plant Biology》2023年第7期1651-1669,共19页Yalu Guo Yiqing Tan Minghao Qu Kai Hong Longjun Zeng Lei Wang Chuxiong Zhuang Qian Qian Jiang Hu Guosheng Xiong 
supported by the Nature Science Foundation of China (31961143015 To G.X.);Hainan Yazhou Bay Laboratory (B21HJ0215 To J.H)。
Drought stress is a major environmental factor that limits the growth, development, and yield of rice(Oryza sativa L.). Histone deacetylases(HDACs) are involved in the regulation of drought stress responses. HDA704 is...
关键词：drought stress HDA704 histone acetylation OsABI5 OsWR2 RICE 
Histone deacetylase OsHDA706 increases salt tolerance via H4K5/K8 deacetylation of OsPP2C49 in rice被引量：4
《Journal of Integrative Plant Biology》2023年第6期1394-1407,共14页Kai Liu Jijin Chen Shang Sun Xu Chen Xinru Zhao Yingying Hu Guoxiao Qi Xiya Li Bo Xu Jun Miao Chao Xue Yong Zhou Zhiyun Gong 
supported by grants from the National Natural Science Foundation of China(31871232);the Jiangsu Province Government(JBGS[2021]001);the Natural Science Foundation of Jiangsu Province(BK20200947);the State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources(SKLCUSA-b202003);the Project of Zhongshan Biological Breeding Laboratory(BM2022008-02);the Fund of Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
High salt is a major environmental factor that threatens plant growth and development.Increasing evidence indicates that histone acetylation is involved in plant responses to various abiotic stress;however,the underly...
关键词：histone deacetylase OsHDA706 OsPP2C49 RICE salt stress 
Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation被引量：3
《Acta Pharmacologica Sinica》2023年第5期1038-1050,共13页Dan-Qian Chen Lin Chen Yan Guo Xia-Qing Wu Ting-Ting Zhao Hai-Ling Zhao Hao-Jun Zhang Mei-Hua Yan Guo-Qiang Zhang Ping Li 
supported by the National Natural Science Foundation of China(Grant No.82104511,82174296);the Project funded by China Postdoctoral Science Foundation(Grant No.2021M693579);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(GrantNo:ZYYCXTD-C-202005).
Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease.Inhibition of fibroblast activation attenuates renal interstitial fibrosis.Our previous stud...
关键词：renal interstitial fibrosis sirt3 poricoic acid A Β-CATENIN DEACETYLATION fibroblast activation unilateral ureteral obstruction(UUO) 
Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice被引量：2
《Gastroenterology Report》2023年第1期316-330,共15页Peng Wang Ruikai Li Yuqi Li Siwei Tan Jie Jiang Huiling Liu Xiuqing Wei 
supported by the Science and Technology Foundation of Guangzhou,China[No.201903010099].
Background:Berberine effectively alleviates non-alcoholic fatty liver disease(NAFLD).Nevertheless,the mechanism is incompletely comprehended.It has been reported that SIRT1 mediates lipid metabolism in liver and berbe...
关键词：BERBERINE non-alcoholic fatty liver disease SIRT1 carnitine palmitoyltransferase 1A ACETYLATION 
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