酶联免疫吸附法(ELISA)检测阿尔茨海默病尿液生物标志物的研究进展  

Research Progress in Detecting Urinary Biomarkers of Alzheimer’s Disease by Enzyme-Linked Immunosorbent Assay

作　　者：黄晓慧 刘征 金贺 HUANG Xiaohui;LIU Zheng;JIN He(College of Medical Laboratory,Guilin Medical University,Guilin Guangxi 541001,China;Central Laboratory of Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]桂林医学院医学检验学院,广西桂林541001 [2]首都医科大学宣武医院中心实验室,北京100053

出　　处：《中国医疗设备》2024年第11期149-152,164,共5页China Medical Devices

基　　金：国家自然科学基金(82160258);广西自然科学基金(2023GXNSFBA026173)。

摘　　要：阿尔茨海默病(Alzheimer’s Disease,AD)作为老年痴呆最主要的类型,其患者数量增长快速。鉴于AD病程的不可逆性,早期筛查和诊断对采取必要的干预措至关重要。尿液标本检测具有方便、无创、患者接受程度高、适于筛查的优势,近年来在生物标志物开发和应用领域受到了重点关注。本文拟对采用酶联免疫吸附法检测AD尿液生物标志物的最新进展进行概述,旨在为AD体液生物标志物的开发和临床应用研究提供新思路。Alzheimer’s disease(AD)is the main type of dementia,and the number of AD patients is increasing rapidly as the population ages.Considering the irreversible nature of AD progression,early screening and diagnosis of AD are essential for timely interventions.Urine sample detection has the advantages of convenience,non-invasive,high patient acceptance and suitable for screening,and has been paid more attention to in the field of biomarker development and application in recent years.This paper summarized the latest research progress in detecting urinary biomarkers of AD by enzyme-linked immunosorbent assay,aiming to provide new ideas for the development and clinical application AD biomarkers.

关 键 词：阿尔茨海默病 生物标志物 尿液 酶联免疫吸附法 磁共振成像 认知功能障碍 外泌体 

分 类 号：R74[医药卫生—神经病学与精神病学]