盐酸米诺环素软膏与替硝唑辅助根管治疗牙周-牙髓病变患者的临床效果  

Clinical effect of minocycline hydrochloride ointment and tinidazole assisted root canal therapy in patients with periodontal-endodontic lesions

作　　者：彭晶晶 马梦星 PENG Jingjing;MA Mengxing(Dental and Dental Pulp Department,Xuchang Haobo Stomatological Hospital,Xuchang 461000,China;Dongcheng First Clinic,Xuchang Haobo Stomatological Hospital,Xuchang 461000,China)

机构地区：[1]许昌皓博口腔医院牙体牙髓科,河南许昌461000 [2]许昌皓博口腔医院东城第一门诊,河南许昌461000

出　　处：《临床医学研究与实践》2024年第31期127-130,共4页Clinical Research and Practice

摘　　要：目的分析盐酸米诺环素软膏与替硝唑辅助根管治疗牙周-牙髓病变患者的临床效果。方法选择2021年6月至2022年12月收治的86例牙周-牙髓病变患者作为研究对象,以随机数字表法将其分为对照组和研究组,各43例。两组均接受根管治疗,在此基础上,对照组给予替硝唑治疗,研究组在对照组基础上使用盐酸米诺环素软膏治疗。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的探诊深度(PD)、龈沟出血指数(SBI)、菌斑指数(PLI)及牙龈指数(GI)低于对照组,根尖暗影最大水平直径(X)及最大垂直直径(Y)高于对照组(P<0.05)。治疗后,研究组的胸腺基质淋巴细胞生成素(TSLP)、白细胞介素-33(IL-33)、细胞间黏附分子-1(ICAM-1)及白细胞介素-1β(IL-1β)水平低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论盐酸米诺环素软膏与替硝唑辅助根管治疗牙周-牙髓病变患者的临床效果显著,有助于改善牙周情况,降低炎症反应,具有较高应用价值。Objective To analyze the clinical effect of minocycline hydrochloride ointment and tinidazole assisted root canal therapy in patients with periodontal-endodontic lesions.Methods A total of 86 patients with periodontal-endodontic lesions admitted from June 2021 to December 2022 were selected as the research objects,and the patients were divided into control group and study group by random number table method,with 43 cases in each group.Both groups received root canal therapy.On this basis,the control group was treated with tinidazole,and the study group was treated with minocycline hydrochloride ointment on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the probing depth(PD),sulcus bleeding index(SBI),plaque index(PLI)and gingival index(GI)in the study group were lower than those in the control group,maximum horizontal diameter(X)and maximum vertical diameter(Y)of apical shadow were higher than those in the control group(P<0.05).After treatment,the levels of thymic stromal lymphopoietin(TSLP),interleukin-33(IL-33),intercellular adhesion molecule-1(ICAM-1)and interleukin-1β(IL-1β)in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Minocycline hydrochloride ointment and tinidazole assisted root canal therapy in patients with periodontal-endodontic lesions has significant clinical effect,which is helpful to improve periodontal condition and reduce inflammatory reaction,and has high application value.

关 键 词：牙周-牙髓病变 根管治疗 盐酸米诺环素软膏 替硝唑 

分 类 号：R781.05[医药卫生—口腔医学]