Coactivator-independent vitamin D receptor signaling causes severe rickets in mice,that is not prevented by a diet high in calcium,phosphate,and lactose  

作　　者：Stefanie Doms Lieve Verlinden Iris Janssens Justine Vanhevel Roy Eerlings RenéHoutman Shigeaki Kato Chantal Mathieu Brigitte Decallonne Geert Carmeliet Annemieke Verstuyf 

机构地区：[1]Department of Chronic diseases and metabolism,Laboratory of Clinical and Experimental Endocrinology,KU Leuven,Leuven,Belgium [2]Department of Cellular and Molecular Medicine,Laboratory of Molecular Endocrinology,KU Leuven,Leuven,Belgium [3]Institute of Applied Microbiology,RWTH Aachen University,Aachen,Germany [4]Precision Medicine Lab,Oss,The Netherlands [5]Health Sciences Research Center,Iryo Sosei University,Iwaki,Fukuchima,Japan [6]Research Institute of Innovative Medicine,Tokiwa Foundation,Iwaki,Fukuchima,Japan

出　　处：《Bone Research》2024年第3期648-660,共13页骨研究（英文版）

基　　金：the University of Leuven (C16/18/006);the Flanders Research Foundation (FWO;G0D0120N,G0D4217N and G081723N)。

摘　　要：The vitamin D receptor(VDR)plays a critical role in the regulation of mineral and bone homeostasis.Upon binding of 1α,25-dihydroxyvitamin D_(3) to the VDR,the activation function 2(AF2)domain repositions and recruits coactivators for the assembly of the transcriptional machinery required for gene transcription.

关 键 词：VITAMIN HOMEOSTASIS POSITIONS 

分 类 号：R591.44[医药卫生—内科学]