阿托伐他汀联合尤瑞克林治疗老年急性脑梗死患者的临床疗效研究  

Clinical Efficacy of Atorvastatin Combined with Eurekulin in the Treatment of Acute Cerebral Infarction in Elderly Patients and Its Effect on Vascular Endothelial Function

作　　者：张岳 ZHANG Yue(Department of Neurology,Quanzhou First Hospital,Fujian Province,Quanzhou 362000,China)

机构地区：[1]福建省泉州市第一医院神经内科,泉州362000

出　　处：《中国医药指南》2024年第31期93-96,共4页Guide of China Medicine

摘　　要：目的研究阿托伐他汀联合尤瑞克林治疗老年急性脑梗死的效果。方法选择2023年4月至2024年2月泉州市第一医院纳入的93例老年急性脑梗死患者,按随机列表法分为两组,观察组47例使用阿托伐他汀联合尤瑞克林,对照组46例使用阿托伐他汀,对比两组总有效率、血管内皮功能指标、炎性指标、神经功能损伤(NIHSS)、日常生活活动能力(ADL)评分。结果观察组总有效率91.49%高于对照组73.91%(P<0.05);观察组不良反应发生率8.51%和对照组15.22%相比无差异(P>0.05)。用药后两组eNOS、SDF-1均升高且观察组更高,但两组ET-1降低且观察组更低(P<0.05);用药后两组IL-6、hs-CRP、IL-8、TNF-α均降低且观察组更低(P<0.05);用药后,两组NIHSS评分均降低且观察组更低,但两组ADL都升高且观察组更高(P<0.05)。结论对于老年急性脑梗死患者而言,经阿托伐他汀联合尤瑞克林治疗的效果显著,同时促进血管内皮功能改善,减轻炎性反应,并改善患者神经功能,使其日常生活能力提升,且安全性高。Objective To investigate the efficacy of atorvastatin combined with urokinase in the treatment of acute cerebral infarction in elderly patients.Methods A total of 93 elderly patients with acute cerebral infarction enrolled in Quanzhou First Hospital from April 2023 to February 2024 were divided into two groups according to random list method 47 patients in the observation group received atorvastatin combined with Ureicrin,and 46 patients in the control group received atorvastatin.The total effective rate,vascular endothelial function index,inflammatory index,nerve function impairment(NIHSS),and activity of daily living(ADL)scores of the two groups were compared.Results The total effective rate of 91.49%in the observation group was higher than that of 73.91%in the control group(P<0.05),there was no significant difference between the incidence rate of adverse reactions of 8.51%in the observation group and that of 15.22%in the control group(P>0.05).After treatment,eNOS and SDF-1 were increased in both groups and higher in observation group,but ET-1 was decreased in both groups and lower in observation group(P<0.05).After treatment,IL-6,hs-CRP,IL-8 and TNF-αwere decreased in both groups,and lower in observation group(P<0.05).After treatment,NIHSS score was decreased in both groups and lower in observation group,but ADL was increased in both groups and higher in observation group(P<0.05).Conclusions For elderly patients with acute cerebral infarction,the effect of treatment with atorvastatin combined with eurythmyelin is remarkable,and at the same time promotes the improvement of vascular endothelial function,reduces the inflammatory response,and improves the patients'neurological function,so that their daily life ability is enhanced,and it is safe.

关 键 词：阿托伐他汀 尤瑞克林 老年急性脑梗死 血管内皮功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]