高健生治疗糖尿病视网膜病变的用药规律分析  

Analysis of GAO Jiansheng's Medication Patterns in the Treatment of Diabetic Retinopathy

作　　者：吴琦 严京[1] 高健生[1] 接传红[1] 刘思言 吕玉欣 吴正正[1] WU Qi;YAN Jing;GAO Jiansheng;JIE Chuanhong;LIU Siyan;LV Yuxin;WU Zheng-zheng(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040

出　　处：《中国中医眼科杂志》2024年第11期1016-1021,共6页China Journal of Chinese Ophthalmology

基　　金：中央级公益性科研院所基本科研课题(ZZ11-087);北京市科技计划课题(Z211100002921024)。

摘　　要：目的基于数据挖掘分析首都国医名师高健生治疗糖尿病视网膜病变(DR)的用药规律。方法纳入2014年1月—2019年1月高健生诊治的DR患者病历,将病历的信息录入Excel软件建立数据库,对处方中的中药名称进行规范化处理。采用古今医案云平台(V2.3.2)统计中药属性和高频中药的使用频次,对高频中药进行关联规则分析、制作关联分析图,并进行聚类分析,应用数据挖掘中的复杂网络分析功能绘制复杂网络分析图。结果(1)中药属性:共得到中药处方87个,涉及中药115味,累计使用频次为1,231次。使用频次≥20次的中药(高频中药)有17味。四气以寒性(451次,37.59%)最多,五味以甘味(740次,37.17%)最多,归经以肝经(813次,24.61%)最多。(2)高频中药使用频次:使用频次排在前5位的依次是黄芪(84次,6.82%)、黄连(75次,6.09%)、密蒙花和肉桂(各73次,5.93%)、益母草(71次,5.77%)。(3)高频中药关联分析:关联性最高的前5位为黄连-黄芪、密蒙花-黄连、密蒙花-黄芪、黄连-肉桂、肉桂-黄芪。(4)高频中药聚类分析:可得到4类组合,功效分别是益气养阴、活血明目;益肾健脾祛湿;活血散瘀;温阳通脉。(5)复杂网络分析:核心药物组成为黄芪、黄连、肉桂、密蒙花、益母草、乌梅、女贞子。结论DR病机多由阴虚燥热向气阴两虚转变,最后发展为阴阳两虚,而瘀血阻络多贯穿病情进展的始终。治疗以心肾论治为特点,多用补气、养阴、助阳药,加以活血散瘀、健脾祛湿之品。OBJECTIVE To analyze the medication patterns of GAO Jiansheng who is renowned Traditional Chinese Medicine masters in the Capital in the treatment of diabetic retinopathy(DR)through data mining.METHODS Medical records of DR patients treated by GAO Jiansheng from January,2014 to January,2019 were included in the study.The information from these medical records was entered into an Excel database,and the names of Chinese medicines in the prescriptions were standardized.The Ancient and Modern Medical Case Cloud Platform(V2.3.2)was used to statistically analyze the properties of Chinese medicines and the usage frequency of high-frequency Chinese medicines.Association rule analysis and cluster analysis were performed on high-frequency Chinese medicines,association analysis graphs were created,and a complex network analysis graph was generated using the complex network analysis function of data mining.RESULTS(1)Properties of Chinese medicines:A total of 87 prescriptions involving 115 Chinese medicines were identified,with a cumulative usage frequency of 1,231 times.Seventeen Chinese medicines had a usage frequency of≥20 times(high-frequency Chinese medicines).Among the"Four Qi"properties,cold(451 times,37.59%)was the most common.Among the"Five Flavors",sweet(740 times,37.17%)was the most common.Regarding meridian entry,liver meridian(813 times,24.61%)was the most frequently entered.(2)Frequency of high-frequency Chinese medicines:The top five Chinese medicines in terms of usage frequency were Astragalus membranaceus(84 times,6.82%),Coptis chinensis(75 times,6.09%),Buddleja officinalis and Cinnamomum cassia(73 times each,5.93%),and Leonurus japonicus(71 times,5.77%).(3)Association analysis of high-frequency Chinese medicines:The top five highest associations were Coptis chinensis-Astragalus membranaceus,Buddleja officinalis-Coptis chinensis,Buddleja officinalis-Astragalus membranaceus,Coptis chinensis-Cinnamomum cassia,and Cinnamomum cassia-Astragalus membranaceus.(4)Cluster analysis of high-frequency Chinese medicines

关 键 词：糖尿病视网膜病变 用药规律 数据挖掘 心肾论治 高健生 

分 类 号：R774.1[医药卫生—眼科] R276.7[医药卫生—临床医学]