基于数据挖掘探讨《眼科纂要》治疗外、内障眼病用药规律  

Exploring the Medication Patterns for Treating External and Internal Ocular Diseases in Yanke Zuanyao Based on Data Mining

作　　者：杨伟杰 傅敏敏 徐红[2] 钱家骅 YANG Weijie;FU Minmin;XU Hong;QIAN Jiahua(Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院,上海200025 [2]上海中医药大学附属龙华医院,上海200020 [3]上海中医药大学附属普陀医院,上海200062

出　　处：《中国中医眼科杂志》2024年第11期1022-1028,共7页China Journal of Chinese Ophthalmology

基　　金：上海市金山区医学重点专科项目(JSZK2023H05)。

摘　　要：目的运用数据挖掘技术探析《眼科纂要》治疗外、内障眼病的用药规律。方法纳入《眼科纂要》中治疗外障眼病和内障眼病的内服方剂,分别将其中医诊断、处方用药信息录入Excel软件建立数据库,对中药名称进行规范化处理后,采用中医传承辅助平台(V2.5)的数据分析和挖掘功能模块进行分析,包括药物的使用频次、性味归经、高频次药对、功效统计及聚类分析。使用IBM SPSS Modeler 18.0进行关联规则分析。结果(1)一般情况:共纳入中药处方115个,其中治疗外障眼病的处方为70个,内障眼病的处方为45个。外障眼病共32种,内障眼病16种。共涉及中药222味,其中治疗外障眼病的中药共98味,累计频次631次;治疗内障眼病的中药共124味,累计频次430次。(2)中药属性:治疗外障眼病的中药四气以寒性最多(325次,51.51%),五味以苦味最多(355次,36.30%),归经以肺经最多(301次,16.97%)。治疗内障眼病的中药四气以温性最多(169次,39.30%),五味以甘味最多(235次,33.19%),归经以肝经用药最多(224次,19.50%)。(3)高频中药使用频次:治疗外障眼病使用频次≥10次的中药(外障高频)共26味,排在前5位的分别是甘草、当归、黄芩、黄连、防风。治疗内障眼病使用频次≥10次的中药(内障高频)共11味,排在前5位的分别是甘草、当归、川芎、生地黄、人参。(4)高频中药功效分类:治疗外障眼病的高频中药以清热药最多,其次为解表药、利水渗湿药、补虚药、活血药和理气药。治疗内障眼病的高频中药以补虚药最多,其次为解表药、活血药、清热药、利水渗湿药。(5)高频中药关联分析:外障高频中药相关性最高的前5位是陈皮-甘草、生地黄-当归、连翘-甘草、荆芥-甘草、川芎-当归。内障高频中药相关性最高的前5位是防风-甘草、川芎,当归-甘草、羌活-甘草、川芎-甘草、生地黄-当归。(6)高频中药聚类分析:外障眼�OBJECTIVE To analyze the medication patterns in Yanke Zuanyao for treating external and internal ocular diseases using data mining techniques.METHODS Internal prescriptions for treating external and internal ocular diseases recorded in Yanke Zuanyao were included.Information on Traditional Chinese Medicine(TCM)diagnoses and prescriptions was entered into Excel software to establish a database.After standardizing the names of Chinese medicines,the TCM Inheritance Support System(V2.5)was used to conduct data analysis and mining,including the frequency of Chinese medicine use,odor and meridian tropism,high-frequency Chinese medicine pairs,efficacy statistics,and cluster analysis.IBM SPSS Modeler 18.0 was employed to analyze association rules.RESULTS(1)General information:A total of 115 TCM prescriptions were included,with 70 for external ocular diseases and 45 for internal ocular diseases.There were 32 types of external ocular diseases and 16 types of internal ocular diseases.A total of 222 Chinese medicines were involved,including 98 for external ocular diseases(cumulative frequency:631 times)and 124 for internal ocular diseases(cumulative frequency:430 times).(2)Attributes of Chinese medicines:For external ocular diseases,the most frequently used Chinese medicines were cold in nature(325 times,51.51%),bitter in taste(355 times,36.30%),and associated with lung meridian(301 times,16.97%).For internal ocular diseases,the most frequently used Chinese medicines were warm in nature(169 times,39.30%),sweet in taste(235 times,33.19%),and associated with liver meridian(224 times,19.50%).(3)High-frequency Chinese medicines:For external ocular diseases,26 Chinese medicines were used≥10 times,with the top five being Licorice,Angelica sinensis,Scutellaria baicalensis,Coptis chinensis,and Siler divaricatae.For internal ocular diseases,11 medicines were used≥10 times,with the top five being Licorice,Angelica sinensis,Ligusticum chuanxiong,Rehmannia glutinosa,Ginseng,and Lycii Fructus.(4)Classification of high-frequency Chine

关 键 词：眼科纂要 眼科 中医传承辅助平台 用药规律 数据挖掘 

分 类 号：R774.1[医药卫生—眼科] R276.7[医药卫生—临床医学]