错配修复基因在非转移性结直肠癌组织中的表达水平及临床意义  

Expression Level and Clinical Significance of Mismatch Repair Gene in Non-Metastatic Colorectal Cancer Tissues

作　　者：潘翔珍[1] PAN Xiang-zhen(Shangqiu First People's Hospital,Shangqiu,Henan 476000)

机构地区：[1]河南省商丘市第一人民医院,河南商丘476000

出　　处：《中国肛肠病杂志》2024年第9期1-4,共4页Chinese Journal of Coloproctology

摘　　要：目的:研究非转移性结直肠癌组织中错配修复基因(MMR)的表达水平及临床意义,分析MMR表达与肿瘤病理学特征的相关性。方法:选取2021年3月至2023年4月,本院收治的180例非转移性结直肠癌患者,均接受手术治疗,取术后病理组织标本进行4种MMR蛋白(MLH1、MSH2、MSH6、PMS2)检测,根据检测结果将患者分为缺失组18例和正常组162例,收集2组患者临床资料,进行对照观察。结果:本组180例结直肠癌患者的MMR蛋白表达缺失率为10.00%,其中MLH1蛋白表达缺失率为4.44%,MSH2蛋白表达缺失率为1.11%,MSH6蛋白表达缺失率为2.78%,PMS2蛋白表达缺失率为8.33%。而MMR蛋白表达缺失与非转移性结直肠癌患者的年龄、肿瘤部位、病理分期和病理类型有相关性(P<0.05);其中肿瘤部位、肿瘤分化程度是MLHI、MSH6蛋白表达缺失的影响因素(P<0.05);肿瘤部位和病理类型是MSH2蛋白表达缺失的影响因素(P<0.05);肿瘤部位、分化程度、病理类型则是PMS2蛋白表达缺失的影响因素(P<0.05)。结论:非转移性结直肠癌患者中有较高的MMR蛋白表达缺失率,其主要与肿瘤发生和进展等有关,可作为结直肠癌临床诊断及治疗的重要指标。Objective To investigate the expression level and clinical significance of mismatch repair gene(MMR)in non-metastatic colorectal cancer tissues,and to analyze the correlation between MMR expression and tumor pathological features.Methods A total of 180 patients with non-metastatic colorectal cancer admitted to our hospital from March 2021 to April 2023 were selected,and all of whom received surgical treatment.Four MMR proteins(MLH1,MSH2,MSH6,PMS2)were detected from postoperative pathological tissue samples.According to the detection results,the patients were divided into deletion group(18 cases)and normal group(162 cases).The clinical data of both groups were collected and observed.Results The deletion rate of MMR protein expression in 180 patients with colorectal cancer was 10.00%,among which the deletion rate of MLH1,MSH2,MSH6 and PMS2 protein expression was 4.44%,1.11%,2.78%and 8.33%,respectively.The deletion of MMR protein expression was correlated with age,tumor site,pathological stage and pathological type of patients with non-metastatic colorectal cancer(P<0.05).The tumor site and the degree of tumor differentiation were the factors affecting the expression deletion of MLHI and MSH6 protein(P<0.05).Tumor site and pathological type were the factors affecting the deletion of MSH2 protein expression(P<0.05).Tumor site,differentiation degree and pathologic type were the factors affecting the deletion of PMS2 protein expression(P<0.05).Conclusion There is a high deletion rate of MMR protein expression in patients with non-metastatic colorectal cancer,which is mainly related to tumor occurrence and progression,and can be used as an important indicator for clinical diagnosis and treatment of colorectal cancer.

关 键 词：结直肠癌 非转移性 错配修复基因 病理特征 蛋白表达 

分 类 号：R735.34[医药卫生—肿瘤]